SOCS3 Is Upregulated and Targeted by miR30a-5p in Allergic Rhinitis.

International Archives of Allergy and Immunology
Chun Yuan ZhaoXin Wang

Abstract

Suppressor of cytokine signaling 1 (SOCS1) and SOCS3 play important roles in T helper cell differentiation, which is involved with the pathologic mechanisms of allergic rhinitis (AR). The aim of this study was to evaluate the expression of SOCS1 and SOCS3 in AR and find their regulatory microRNAs (miRNAs) to provide a basis for the treatment of AR. The expression of SOCS1 and SOCS3 were analyzed by real-time PCR, immunohistochemistry, and Western blot. The correlative regulatory miRNAs were detected by real-time PCR. Luciferase assays and AR mouse model experiments were applied to identify correlative miRNAs that target SOCS3. SOCS1 and SOCS3 mRNA were upregulated in the nasal mucosa and peripheral blood mononuclear cells of AR compared with controls. The expression of SOCS3 protein was significantly increased in the nasal mucosa of AR. The immunohistochemical staining results showed that SOCS3 was similarly localized in the superficial epithelium, submucosal glands, and vascular endothelium in the nasal mucosa of AR subjects and controls. However, SOCS3 protein was especially localized in the inflammatory cells, such as eosinophils, monocytes, and lymphocytes. SOCS3 was targeted by miR30a- 5p in AR. Further study should be per...Continue Reading

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Citations

May 30, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Krzysztof Specjalski, Ewa Jassem
Apr 11, 2020·Mediators of Inflammation·Zhou ShangxunHuang Yang
Aug 11, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMarek Sanak
Nov 14, 2018·International Archives of Allergy and Immunology·Olivia Joan Adams, Stephan von Gunten
Nov 7, 2019·International Archives of Allergy and Immunology·Daniëlle Verschoor, Stephan von Gunten

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