Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis

PLoS Genetics
Marc AmoyelErika A Bach

Abstract

The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs), which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs), which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increased JAK/STAT signaling. Here we show that competitive behavior of Socs36E mutant CySCs is due in large part to unbridled Mitogen-Activated Protein Kinase (MAPK) signaling. In Socs36E mutant clones, MAPK activity is elevated. Furthermore, we find that clonal upregulation of MAPK in CySCs leads to their outcompetition of wild type CySCs and of GSCs, recapitulating the Socs36E mutant phenotype. Indeed, when MAPK activity is removed from Socs36E mut...Continue Reading

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Citations

Jan 12, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·N A Siddall, G R Hime
Dec 19, 2017·Frontiers in Endocrinology·Kate L LovelandHans-Christian Schuppe
Dec 19, 2018·International Journal of Molecular Sciences·Sunny Trivedi, Michelle Starz-Gaiano
Jan 31, 2019·Development·Salvador C Herrera, Erika A Bach
Nov 17, 2020·Oxidative Medicine and Cellular Longevity·Wanyin ChenJie Fang
Aug 19, 2021·Cell Reports·Guangming DingWei Song
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Bo ZhangShuangbao Gun

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