Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells

Nutrition Research
Hye-Sook ChangO Yamato

Abstract

There is evidence that onions and garlic protect against cancer in humans. It has been suggested that this effect is partly due to the organosulfur compounds in Allium vegetables and that these substances act through induction of phase II detoxification enzymes. Here, we hypothesized that alk(en)yl thiosulfates, sodium n-propyl thiosulfate (NPTS), and sodium 2-propenyl thiosulfate (2PTS), which were identified in onions and garlic, respectively, may induce phase II enzymes. Therefore, rat hepatoma cells (H4IIE) were cultured with 1 to 100 micromol/L of NPTS or 2PTS for 48 hours at 37 degrees C; and the activities and messenger RNA (mRNA) expression levels of phase II enzymes in H4IIE cells were investigated. The effects of diallyl trisulfide and tert-butylhydroquinone, known as phase II inducers, were also examined as positive controls and compared with the responses of NPTS and 2PTS. Quinone reductase (QR) activity and mRNA expression levels of QR and epoxide hydrolase 1 were significantly increased by 2PTS (P < .05-.005). In particular, QR activity was increased at a relatively low concentration of 2PTS (10 micromol/L). However, glutathione S-transferase activity and mRNA expression levels of glutathione S-transferase A5 and ...Continue Reading

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Citations

Mar 22, 2012·Antioxidants & Redox Signaling·Benjamin Lee PredmoreGabriel Gojon
Aug 30, 2019·Phytotherapy Research : PTR·Yahya AsemaniZahra Amirghofran
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MiękusArtur H Świergiel
Jan 24, 2019·Dose-response : a Publication of International Hormesis Society·Iram FatimaTariq Mahmood
Aug 10, 2017·International Journal of Molecular Sciences·Michael T Puccinelli, Silvia D Stan
Apr 19, 2019·Journal of Food Science and Technology·Jiwan S SidhuNissar Ahmed
Aug 17, 2021·Nutrition and Cancer·Deepa S Mandlik, Satish K Mandlik

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