Sodium-activated potassium channels are functionally coupled to persistent sodium currents.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Travis A Hage, Lawrence Salkoff

Abstract

We report a novel coupled system of sodium-activated potassium currents (I(KNa)) and persistent sodium currents (I(NaP)), the components of which are widely distributed throughout the brain. Its existence and importance has not been previously recognized. Although I(KNa) was known to exist in many cell types, the source of Na(+) which activates I(KNa) remained a mystery. We now show in single membrane patches generated from the somas of rat neurons that sodium influx through I(NaP) is sufficient for activation of K(Na) channels, without substantial contribution from the transient sodium current or bulk [Na(+)](i). I(NaP) was found to be active at cell membrane resting potentials, a finding that may explain why I(KNa) can be evoked from negative holding potentials. These results show an unanticipated role for I(NaP) in activating a negative feedback system countering the excitable effects I(NaP); the interrelatedness of I(NaP) and I(KNa) suggests new ways neurons can tune their excitability.

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Citations

Jan 1, 2013·Cardiovascular Drugs and Therapy·Antonio Zaza, Marcella Rocchetti
Oct 30, 2013·The Journal of General Physiology·Priyanka GargMichael C Sanguinetti
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yalan ZhangLeonard K Kaczmarek
Dec 10, 2013·ISRN Neuroscience·Leonard K Kaczmarek
Feb 27, 2016·Glia·Christine R Rose, Alexei Verkhratsky
Nov 28, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anthony J Morgan, Antony Galione
Sep 23, 2014·Pflügers Archiv : European journal of physiology·Riccardo RizzettoAntonio Zaza
Nov 21, 2015·The Journal of Comparative Neurology·Sandra RizziChristoph Schwarzer
Sep 23, 2016·Biophysical Journal·Elizabeth J AkinMichael M Tamkun
Sep 30, 2016·The Journal of Physiology·M Hunter GieseMichael C Sanguinetti
Aug 5, 2017·Journal of Cellular Physiology·Ekaterina Pchelintseva, Mustafa B A Djamgoz
Feb 9, 2019·The Journal of Physiology·Alexei VerkhratskyChristine R Rose
Aug 25, 2019·The Journal of Physiology·Ping LiLawrence Salkoff
Mar 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kerri D PryceArin Bhattacharjee
Jan 30, 2016·The Journal of Biological Chemistry·Gonzalo BudelliLawrence Salkoff
Apr 6, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rebekka EhingerRobert Lukowski

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