Sodium-activated potassium conductance participates in the depolarizing afterpotential following a single action potential in rat hippocampal CA1 pyramidal cells

Brain Research
Xinhuai Liu, L Stan Leung

Abstract

The depolarizing afterpotential (DAP) following an action potential increases the excitability of a neuron. Mechanisms related to the DAP following an antidromic or current-induced spike were studied in CA1 pyramidal cells by whole-cell recordings in hippocampal slices in vitro. In DAP-holding voltage curves, the DAP at 10 ms after the spike peak (DAP10) was extrapolated to reverse at about -50 mV. Increase of extracellular K(+) concentration increased DAP and neuronal bursting. DAP10 reversal potential shifted positively with an increase in [K(+)](o) and with the blockade of K(+) conductance using pipettes filled with Cs(+). Similarly, extracellular tetraethylammonium (TEA; 10 mM), 4-aminopyridine (3-10 mM) increased DAP and shifted the DAP10 reversal potential to a depolarizing direction. Decrease of [Ca(2+)](o) did not alter DAP significantly, suggesting a nonessential role of Ca(2+) in the DAP. Perfusion of tetrodotoxin (TTX; 0.1-1 microM) and replacement of extracellular Na(+) by choline(+) suppressed both spike height and DAP simultaneously. Replacement of extracellular Na(+) by Li(+) increased DAP and spike bursts, and caused a positive shift of the DAP10 reversal potential. It is suggested that Li(+) increased DAP by bl...Continue Reading

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Citations

Dec 10, 2013·ISRN Neuroscience·Leonard K Kaczmarek
Dec 29, 2009·Progress in Neurobiology·Dongman Chao, Ying Xia
Aug 25, 2009·Progress in Neurobiology·Arun V KrishnanMatthew C Kiernan
Jul 20, 2010·Brain Research·Charlotte Butler-MunroPhilip M Heyward
Sep 3, 2011·Journal of Zhejiang University. Science. B·Zhou-yan FengHao-yu Xing
Nov 21, 2015·The Journal of Comparative Neurology·Sandra RizziChristoph Schwarzer
Apr 20, 2016·Journal of Neuroendocrinology·V Bansal, T E Fisher
Mar 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yong Zhang, William G Paterson
Mar 3, 2007·Journal of Neurophysiology·Dietmar HessAbdeljabbar El Manira
Sep 9, 2017·Metallomics : Integrated Biometal Science·Magali Roux, Anthony Dosseto
May 1, 2021·International Journal of Molecular Sciences·Santosh RijalSeong Kyu Han
Jun 3, 2021·Trends in Pharmacological Sciences·Bethan A ColeJonathan D Lippiat

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