Sodium alendronate loaded poly(l-lactide- co -glycolide) microparticles immobilized on ceramic scaffolds for local treatment of bone defects

Regenerative Biomaterials
Łucja RumianElżbieta Pamuła

Abstract

Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and healing. Sodium alendronate (Aln), a widely used anti-osteoporosis drug, exhibits strong inhibitory effect on bone resorption performed by osteoclasts. Thus, we propose a new approach for the treatment of bone defects in craniofacial region combining biocompatible titanium dioxide scaffolds and poly(l-lactide-co-glycolide) microparticles (MPs) loaded with Aln. The MPs were effectively attached to the surface of the scaffolds' pore walls by human recombinant collagen. Drug release from the scaffolds was characterized by initial burst (24 ± 6% of the drug released within first 24 h) followed by a sustained release phase (on average 5 µg of Aln released per day from Day 3 to Day 18). In vitro tests evidenced that Aln at concentrations of 5 and 2.5 µg/ml was not cytotoxic for MG-63 osteoblast-like cells (viability between 81 ± 6% and 98 ± 3% of control), but it prevented RANKL-induced formation of osteoclast-like cells from macrophages derived from peripheral blood mononuclear cells, as shown by reduced fusion capa...Continue Reading

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Citations

Oct 18, 2020·International Journal of Molecular Sciences·Małgorzata Krok-BorkowiczElżbieta Pamuła

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Methods Mentioned

BETA
pharmacotherapy
xenografts
GTPases

Software Mentioned

OriginPro
AxioVs40

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