Sodium and calcium ions in the control of temperature set-point in the pigeon

British Journal of Pharmacology
P N Saxena


1 The effect of altering the ionic balance of the cerebrospinal fluid (CSF) on cloacal temperature of unanesthetized pigeons kept at room temperature (20-25 degrees C) was examined by injection or infusion of solutions of different ionic composition into a cannulated lateral cerebral ventricle. 2 An increase in the concentration of calcium ions caused a fall in temperature and behavioural sedation. The effects were the same whether the calcium was present as calcium chloride or as the calcium disodium salt of ethylenediamine tetra-acetic acid (CaNa2EDTA). 3 When the concentration of sodium ions in the CSF perfusate was increased by addition of NaCl or that of calcium ions was decreased by addition of Na2EDTA a rise in temperature was often produced but this was not consistent. NaCl sometimes had either no effect or lowered the temperature. Na2EDTA while producing a rise when first injected failed to do so when repeated a few hours, 24 h and often 72 h later. Prolonged infusion of either agent caused intense behavioural excitement leading to death. 4 Potassium ions, like sodium ions, caused a rise in temperature but only when infused continuously. Behavioural excitement was only rarely observed. 5 Magnesium produced a fall in te...Continue Reading


Aug 1, 1974·British Journal of Pharmacology·N ChawlaK C Singhal
Dec 1, 1972·The American Journal of Physiology·R D Myers, J E Buckman
Nov 1, 1970·The Journal of Physiology·W Feldberg, P N Saxena
Dec 1, 1952·The Journal of Clinical Investigation·H SPENCERD LASZLO

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