PMID: 8945749Nov 8, 1996Paper

Sodium benzoate differentially blocks circling induced by D-and L-dopa in the hemi-parkinsonian rat

Neuroscience Letters
J MosesP B Silverman

Abstract

D-3,4-Dihydroxyphenylalanine (D-dopa) and L-3,4-dihydroxyphenylalanine (L-dopa) induced circling in rats with a unilateral 6-hydroxydopamine lesion of substantia nigra with similar potency. D-Dopa is not a substrate for aromatic L-amino acid decarboxylase, the enzyme which metabolizes L-dopa to dopamine. This raises the question of how D-dopa has behavioral effect. Two pathways have been suggested to result in conversion of D-dopa to L-dopa, one involving oxidation of D-dopa to dihydroxyphenylpyruvic acid (DHPPA) by D-amino acid oxidase, the other involving transamination of D-dopa to DHPPA. Here we show that sodium benzoate, an inhibitor of D-amino acid oxidase, blocks D-dopa-induced circling while having no effect on circling induced by L-dopa. The results suggest that conversion of D-dopa to L-dopa via DHPPA is highly dependent on oxidase activity and that sodium benzoate effectively inhibits this process in vivo in rat.

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Citations

Sep 18, 2007·Cellular and Molecular Neurobiology·Wenjuan ZhaoYong-Xiang Wang
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Jul 24, 2007·Neurotoxicology and Teratology·Huey-Jen TsayYau-Hung Chen
Feb 17, 2007·Biochemical and Biophysical Research Communications·Tomoya KawazoeKiyoshi Fukui
Sep 21, 2007·The European Journal of Neuroscience·Louise VerrallPhilip W J Burnet
Dec 14, 2004·Toxicology·R E Williams, E A Lock
Oct 10, 2007·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Tomoya KawazoeKiyoshi Fukui
Sep 27, 2013·Journal of Neurophysiology·Eric C GustafsonRobert F Miller
Oct 22, 2004·The Journal of Pharmacology and Experimental Therapeutics·Yan-Fei XinYong-Xiang Wang
Oct 19, 2010·The Journal of Pharmacology and Experimental Therapeutics·Nian GongYong-Xiang Wang
Oct 16, 2009·The Journal of Pharmacology and Experimental Therapeutics·Wen-Juan ZhaoYong-Xiang Wang
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