PMID: 1554Feb 2, 1976

Sodium bicarbonate administration during cardiac arrest. Effect on arterial pH PCO2, and osmolality

JAMA : the Journal of the American Medical Association
R L Bishop, M L Weisfeldt

Abstract

Arterial pH, Pco2, and osmolality were determined serially during cardiac resuscitation in patients and in dogs, with and without administration of sodium bicarbonate. These studies demonstrate that (1) in the absence of preexisting acidosis, severe acidosis can be prevented by adequate ventilation alone; (2) sodium bicarbonate administration results in a significant rise in arterial Pco2, which parallels the rise in pH despite adequate ventilation; (3) during prolonged cardiac and resuscitation, there is a rise in arterial osmolality that is accentuated by sodium bicarbonate. These studies suggest that sodium bicarbonate should not be used during resuscitation (1) in the absence of effective hyperventilation or where carbon dioxide removal is inadequate despite adequate ventilation, (2) in repeated doses, without confirmation of substantial acidosis, or (3) when cardiac arrest has been of brief duration and preexisting acidosis is unlikely. These studies also point to the need for a reappraisal of other buffers that do not elevate the arterial Pco2.

Citations

Jun 1, 1992·Archives of Emergency Medicine·D J Steedman, C E Robertson
Jan 1, 1995·Paediatric Anaesthesia·C E Richmond, R M Bingham
May 1, 1981·Chest·J S Huseby, D G Gumprecht
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J A Kraut, I Kurtz
Jun 1, 1979·American Heart Journal·P C Gazes, J E Gaddy
Jun 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·L Landow, M S Visner
Oct 1, 1990·Resuscitation·N N Izzat, J P Rosborough
Nov 1, 1992·The American Journal of Emergency Medicine·B E BleskeA Fieldman
Aug 1, 1982·The American Journal of Cardiology·W W ParmleyM L Weisfeldt
Dec 1, 1994·Journal of Critical Care·R S RaoS M Scharf
Mar 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·S M HartsfieldT Aiken
Jul 1, 1988·Journal of Clinical Pharmacology·M von PlantaE C Rackow
Jul 1, 1988·Annals of Emergency Medicine·P L HennemanJ A Marx
Feb 1, 1993·Annals of Emergency Medicine·M von PlantaN S Abramson
Dec 1, 1979·American Heart Journal·J S Redding
Feb 1, 1990·Journal of the American College of Cardiology·R J GazmuriE C Rackow
Jun 20, 2016·Annals of Emergency Medicine·Jacob C JentzerAllan S Jaffe
Jan 13, 2000·Chest·S M Forsythe, G A Schmidt
May 1, 2002·Current Opinion in Pediatrics·Amer N Ammari, Karl F Schulze

Related Concepts

Metabolic Acidosis
Carbonic Acid Ions
Blood
Carbon Dioxide
Canis familiaris
Cardiac Arrest
Hydrogen-Ion Concentration
Osmolality
Dioxygen
Respiration

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