Sodium Butyrate Ameliorates L-Arginine-Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress

Journal of Biochemical and Molecular Toxicology
Gayathri KanikaGopabandhu Jena

Abstract

Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine (L-Arg)-induced pancreatic fibrosis in Wistar rats. Pancreatic fibrosis was induced by twice intraperitoneal (i.p.) injections of 20% L-Arg (250 mg/100 g) at 2-h interval on day 1, 4, 7, and 10, whereas SB (800 mg/kg/day) was administrated for 10 days. At the end of the study, biochemical estimations, histological alterations, DNA damage, and the expression of various proteins were evaluated. Posttreatment of SB decreased L-Arg-induced oxidative and nitrosative stress, DNA damage, histological alterations, and fibrosis. Interestingly, posttreatment of SB significantly decreased the expression of α-smooth muscle actin, interleukin-1β, inducible nitric oxide synthase, and 3-nitrotyrosine. The present study demonstrated that posttreatment of SB alleviates L-Arg-induced pancreatic damage and fibrosis in rat.

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Citations

Jul 2, 2020·Journal of Biochemical and Molecular Toxicology·Jayant PatwaGopabandhu Jena
Apr 30, 2020·Cancers·Borbála KissPéter Árkosy
Dec 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Pollyana Ribeiro CastroLucíola Silva Barcelos
Apr 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rasoul MirzaeiSajad Karampoor
May 29, 2021·F1000Research·Nithin K KPraveenkumar Shetty

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