Sodium butyrate decreases histamine-stimulated calcium mobilization in C6 glioma cells

Neuroreport
H C OuS H Sun

Abstract

The aim of this study was to investigate the effect of sodium butyrate on calcium mobilization. Histamine was found to stimulate a dose-dependent increase in intracellular calcium concentrations ([Ca2+]i) through H1 receptors, but this effect was attenuated in C6 cells pretreated with 1-5 mM sodium butyrate. Evidence is provided that release of Ca2+ from intracellular stores is decreased in a dose-dependent manner. Experiments with BAPTA that show lower levels of [Ca2+]i in cells pretreated with higher concentrations of sodium butyrate suggest that sodium butyrate also decreases Ca2+ influx. These results suggest that changes in Ca2+ mobilization are at least partially responsible for sodium butylate-induced C6 cell differentiation.

References

Oct 1, 1987·Journal of Cellular Physiology·A Hirschfeld, J Bressler
Apr 29, 1980·Biochemical and Biophysical Research Communications·D Weingarten, J de Vellis
Jan 1, 1994·Molecular and Cellular Endocrinology·M J Berridge

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Citations

May 7, 2004·Neuroreport·Muhammad T ZiaEdmund F La Gamma
Aug 29, 2006·Biochemical and Biophysical Research Communications·Sung Dae KimMan Hee Rhee

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