Sodium Butyrate Improves High-Concentrate-Diet-Induced Impairment of Ruminal Epithelium Barrier Function in Goats

Journal of Agricultural and Food Chemistry
Kai ZhangYunfeng Bai

Abstract

We investigated the effect of sodium butyrate feeding on the disruption of ruminal epithelium barrier function in goats fed a high-concentrate diet. A total of 18 male Boer goats (live weight of 31.75 ± 1.35 kg, aged 1 year) were randomly assigned to three groups, which were fed a low-concentrate diet (LC), a high-concentrate diet (HC), or a high-concentrate diet with 1% sodium butyrate by weight (SH) for 9 weeks. We found that the pH of rumen fluid in the SH and LC groups was higher than that in the HC group. The activity of protein kinase C (PKC) kinase in the rumen epithelium was higher in the HC group than that in the LC and SH groups. The mRNA expression and phosphorylated protein levels of mitogen-activated protein kinases (MAPKs) in the rumen epithelium were lower in the SH and LC groups than those in the HC group. The DNA methylation rate of occludin was higher in the HC group than that in the SH and LC groups. The mRNA and protein expression of claudin-1, claudin-4, occludin, and zona occludin-1 was greater in the SH and LC groups than that in the HC group. In addition, sodium butyrate mitigated damage to the rumen epithelium caused by the HC diet. Together, our results suggest that the supply of sodium butyrate revers...Continue Reading

References

Oct 14, 1998·International Review of Cytology·K Matter, M S Balda
Feb 11, 2000·European Journal of Cell Biology·T InaiY Shibata
Feb 23, 2000·The Journal of Cell Biology·D Li, R J Mrsny
Jun 16, 2000·Advanced Drug Delivery Reviews·H ClarkeJ M Mullin
Dec 5, 2000·Molecular Biology of the Cell·M SaitouS Tsukita
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·S TsukitaM Itoh
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·N GasslerF Autschbach
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 25, 2003·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Takashi KojimaNorimasa Sawada
May 22, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H MartensK Wolf
Feb 4, 2005·American Journal of Physiology. Cell Physiology·Alan S L YuEveline E Schneeberger
Apr 12, 2005·Advanced Drug Delivery Reviews·Gemma J FeldmanMichael P Ryan
Apr 14, 2005·Journal of Hepatology·Toshinobu YamamotoNorimasa Sawada
May 23, 2007·Journal of Dairy Science·T G Nagaraja, E C Titgemeyer
Nov 23, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·X WuK Jacobson
Jan 26, 2008·Journal of Dairy Science·D G V EmmanuelB N Ametaj
Jun 10, 2008·Current Molecular Medicine·Mélanie G GareauMary H Perdue
Jan 6, 2009·Biochimica Et Biophysica Acta·Maria S Balda, Karl Matter
Feb 24, 2009·Journal of Dairy Science·P GuilloteauY Hamon
Jul 17, 2009·American Journal of Physiology. Cell Physiology·Fabio CarrozzinoRoberto Montesano
Aug 12, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Meng-Horng LeeStelios T Andreadis
Mar 19, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rana Al-SadiThomas Ma
Apr 1, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael A SteeleBrian W McBride
May 4, 2011·The Journal of Cell Biology·David R RaleighJerrold R Turner
Jul 13, 2011·Digestive Diseases and Sciences·Lisa S PoritzWalter A Koltun
Jun 7, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jun-hua LiuSheng-yong Mao
Dec 3, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tanira A S AguirreDavid J Brayden
Jul 15, 2015·Methods in Molecular Biology·Thomas S Hnasko, Robert M Hnasko

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Citations

Apr 12, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Junhua LiuShengyong Mao

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