PMID: 8610506Jan 1, 1995Paper

Sodium-calcium relationships and cardiac function during coronary bolus perfusion

Acta Radiologica. Supplementum
P JyngeA Oksendal

Abstract

The present review deals with the side-effects of contrast media (CM) on cardiac function during coronary angiography. A physiological approach is used to redefine existing concepts of CM osmotoxicity and chemotoxicity in terms of osmolal, ionic and molecular effects. The main idea conveyed is that purely ionic effects are of central importance during and immediately following the transit of a brief coronary bolus. Ionic effects result largely from rapid transient washout of normal extracellular ions, but are also influenced by ions present in the CM. In particular, the calcium (Ca) and sodium (Na) ions controlling cardiac function are easily affected. The myocardial Na-Ca exchange, which is mainly a physiological mechanism for cellular Ca efflux during cardiac relaxation, is therefore highlighted in detail. The importance of avoiding a potential Na-Ca mismatch is shown by examples from basic physiology, cardiac surgery and coronary angiography and by results of experiments with Visipaque. In the isomolal and isotonic CM Visipaque, which is based on the dimer isodixanol (320 mg I/ml), an available osmolal space is filled with an appropriately balanced supplement consisting of NaCl (19mM) and CaCl2 (0.3 mM).

References

Jan 1, 1977·Annual Review of Medicine·G A Langer
Mar 1, 1979·The American Journal of Physiology·L J Mullins
Feb 1, 1979·Journal of Molecular and Cellular Cardiology·J H TillischG A Langer
Nov 1, 1992·Trends in Pharmacological Sciences·P A Revest, N J Abbott
Oct 11, 1992·Trends in Pharmacological Sciences·O P HamillD W McBride
Mar 1, 1992·Trends in Pharmacological Sciences·J A SmithM J Lewis
Apr 1, 1992·Cardiovascular Research·S A Ben-HaimO S Better
Dec 12, 1991·Biochimica Et Biophysica Acta·B Sarkadi, J C Parker
Apr 1, 1991·The American Journal of Cardiology·E BrennanV J Aharonian
Nov 1, 1990·Journal of Molecular and Cellular Cardiology·B Lewartowski, K Zdanowski
Oct 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D J AdamsC Van Breemen
Apr 1, 1989·The American Journal of Physiology·M J Shattock, D M Bers
May 1, 1986·Progress in Cardiovascular Diseases·P C HanleyH C Smith
Oct 1, 1986·The British Journal of Radiology·P Dawson, M Howell
Oct 1, 1985·Journal of Molecular and Cellular Cardiology·A N OksendalT Saetersdal
Oct 5, 1973·Circulation Research·P I Polimeni, E Page
Oct 1, 1983·Journal of Molecular and Cellular Cardiology·G A Langer
Jan 1, 1982·Annual Review of Physiology·G A Langer
May 1, 1981·Canadian Journal of Physiology and Pharmacology·C N Fong, J A Hinke
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J HoyerH Gögelein

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Citations

Jul 3, 1999·Physiological Reviews·M P Blaustein, W J Lederer
Jul 6, 2000·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A BergstraH J Crijns
Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson

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