Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti

Yuzhe DuKe Dong


Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides. Mutations in the sodium channel have been shown to be responsible for pyrethroid resistance, known as knockdown resistance (kdr), in various insects including mosquitoes. In Aedes aegypti mosquitoes, the principal urban vectors of dengue, zika, and yellow fever viruses, multiple single nucleotide polymorphisms in the sodium channel gene have been found in pyrethroid-resistant populations and some of them have been functionally confirmed to be responsible for kdr in an in vitro expression system, Xenopus oocytes. This mini-review aims to provide an update on the identification and functional characterization of pyrethroid resistance-associated sodium channel mutations from Aedes aegypti. The collection of kdr mutations not only helped us develop molecular markers for resistance monitoring, but also provided valuable information for computational molecular modeling of pyrethroid receptor sites on the sodium channel.


Jan 1, 1989·Annual Review of Entomology·David M Soderlund, J R Bloomquist
Jul 1, 1996·Pharmacology & Toxicology·T Narahashi
Feb 16, 2006·The Biochemical Journal·A O O'ReillyT G E Davies
Aug 5, 2010·The American Journal of Tropical Medicine and Hygiene·Angela F HarrisHilary Ranson
Jun 29, 2011·Archives of Toxicology·David M Soderlund
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christopher M JonesCraig S Wilding
Jul 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuzhe DuKe Dong
Sep 11, 2013·Pesticide Biochemistry and Physiology·Frank D RinkevichKe Dong
Oct 8, 2013·Experimental Physiology·William A Catterall
Jan 17, 2014·Parasites & Vectors·Jutta Gerlinde Birggitt LinssAdemir Jesus Martins
Apr 8, 2014·Insect Biochemistry and Molecular Biology·Ke DongBoris S Zhorov
Oct 31, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Francesca Guaracyaba Garcia ChapadensePedro Cravo
Nov 21, 2015·PLoS Neglected Tropical Diseases·Isabelle DusfourClare Strode
Dec 15, 2015·PLoS Neglected Tropical Diseases·Farah Z Vera-MaloofWilliam C Black Iv
Oct 16, 2016·Pesticide Biochemistry and Physiology·Letícia B SmithJeffrey G Scott


Mar 30, 2017·Parasites & Vectors·Oscar Alexander Aguirre-ObandoMário Antônio Navarro-Silva
Feb 23, 2019·PloS One·Yashoda KandelImmo A Hansen
May 5, 2018·Parasites & Vectors·Marissa K GrossmanGonzalo M Vazquez-Prokopec
Aug 10, 2019·PLoS Neglected Tropical Diseases·Taciano P FerreiraRaimundo W S Aguiar
Apr 17, 2020·PLoS Neglected Tropical Diseases·Luciano Veiga CosmeAdemir Jesus Martins
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
Jun 25, 2019·PloS One·Tri Baskoro Tunggul Satoto Kuswati
Aug 9, 2020·Scientific Reports·Monique Melo CostaAdemir Jesus Martins
Apr 19, 2019·BMJ Case Reports·L R van den BersselaarB de Jong

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