Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti

Insects
Yuzhe DuKe Dong

Abstract

Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides. Mutations in the sodium channel have been shown to be responsible for pyrethroid resistance, known as knockdown resistance (kdr), in various insects including mosquitoes. In Aedes aegypti mosquitoes, the principal urban vectors of dengue, zika, and yellow fever viruses, multiple single nucleotide polymorphisms in the sodium channel gene have been found in pyrethroid-resistant populations and some of them have been functionally confirmed to be responsible for kdr in an in vitro expression system, Xenopus oocytes. This mini-review aims to provide an update on the identification and functional characterization of pyrethroid resistance-associated sodium channel mutations from Aedes aegypti. The collection of kdr mutations not only helped us develop molecular markers for resistance monitoring, but also provided valuable information for computational molecular modeling of pyrethroid receptor sites on the sodium channel.

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Citations

Mar 30, 2017·Parasites & Vectors·Oscar Alexander Aguirre-ObandoMário Antônio Navarro-Silva
Feb 23, 2019·PloS One·Yashoda KandelImmo A Hansen
May 5, 2018·Parasites & Vectors·Marissa K GrossmanGonzalo M Vazquez-Prokopec
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Apr 17, 2020·PLoS Neglected Tropical Diseases·Luciano Veiga CosmeAdemir Jesus Martins
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
Jun 25, 2019·PloS One·Tri Baskoro Tunggul Satoto Kuswati
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Related Concepts

Biological Markers
Dengue Fever
Disease Vectors
Genes
Genetic Vectors
Insecta
Culicidae
Sodium Channel
Virus
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