Sodium Chloride Supplementation Is Not Routinely Performed in the Majority of German and Austrian Infants with Classic Salt-Wasting Congenital Adrenal Hyperplasia and Has No Effect on Linear Growth and Hydrocortisone or Fludrocortisone Dose

Hormone Research in Pædiatrics
Walter BonfigKlaus Mohnike

Abstract

Sodium chloride supplementation in salt-wasting congenital adrenal hyperplasia (CAH) is generally recommended in infants, but its implementation in routine care is very heterogeneous. To evaluate oral sodium chloride supplementation, growth, and hydrocortisone and fludrocortisone dose in infants with salt-wasting CAH due to 21-hydroxylase in 311 infants from the AQUAPE CAH database. Of 358 patients with classic CAH born between 1999 and 2015, 311 patients had salt-wasting CAH (133 females, 178 males). Of these, 86 patients (27.7%) received oral sodium chloride supplementation in a mean dose of 0.9 ± 1.4 mmol/kg/day (excluding nutritional sodium content) during the first year of life. 225 patients (72.3%) were not treated with sodium chloride. The percentage of sodium chloride-supplemented patients rose from 15.2% in children born 1999-2004 to 37.5% in children born 2011-2015. Sodium chloride-supplemented and -unsupplemented infants did not significantly differ in hydrocortisone and fludrocortisone dose, target height-corrected height-SDS, and BMI-SDS during the first 2 years of life. In the AQUAPE CAH database, approximately one-third of infants with salt-wasting CAH receive sodium chloride supplementation. Sodium chloride supp...Continue Reading

References

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Nov 2, 2016·Hormone Research in Pædiatrics·Carla BizzarriStefano Cianfarani

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Citations

Nov 21, 2019·Clinical Endocrinology·Marianna MinnettiMartin O Savage
Oct 3, 2018·The Journal of Clinical Endocrinology and Metabolism·Phyllis W SpeiserPerrin C White
May 18, 2019·Archives of Disease in Childhood·Emmanuel AmeyawJean-Pierre Chanoine
May 8, 2021·Endocrine Reviews·Hedi L Claahsen-van der GrintenPerrin C White

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