Sodium citrate: an alternative antacid for prophylaxis against aspiration pneumonitis

Anaesthesia and Intensive Care
J WrobelJ M Saunders


In a double-blind study, 107 patients undergoing elective and emergency surgical procedures were given 15 ml of either sodium citrate 0.3 M or placebo 10 minutes before induction of anaesthesia. Gastric contents were sampled immediately after induction and the pH was measured. The mean pH of the Gastric contents of patients given sodium citrate was 5.67, whereas for those given the placebo it was 3.21 (p less than 0.001). Of patients given sodium citrate 92% had a gastric pH above 3.0 compared with only 37% in the placebo group (p less than 0.001). At the end of surgery gastric contents were emptied as completely as possible and the volume and pH measured. There was no significant difference in the mean volume of gastric contents in the two groups. In neither group was the mean pH at the end of surgery significantly different from that after induction.


Oct 1, 1978·Anaesthesia·R P HusemeyerT Rajasekaran
Oct 1, 1979·British Journal of Anaesthesia·G DobbJ G Williams
Apr 15, 1978·Lancet·W A Mahon, M Kolton
Nov 3, 1979·Lancet·R Chakrabarti, S G Thompson
Apr 12, 1979·The New England Journal of Medicine·J L McDaniel, J J Stein
Nov 1, 1979·Anesthesiology·C P GibbsE J Kuck
Sep 29, 1979·British Medical Journal·J CohenD M Krikler
Nov 24, 1979·British Medical Journal·S Ahmad
Feb 2, 1978·The New England Journal of Medicine·C G Brook
Nov 1, 1973·British Journal of Anaesthesia·S K LahiriR M Hodgson
Nov 1, 1974·Anesthesia and Analgesia·R B Roberts, M A Shirley
Jan 1, 1970·British Journal of Anaesthesia·J S Crawford


Feb 1, 1985·Anaesthesia and Intensive Care·B L DuffyC M Scanlan
Sep 1, 1987·Anaesthesia·R Burgess, J Wrobel

Related Concepts

General Anesthesia
Double-Blind Method
Gastric Acidity Determination
Aspiration Pneumonia
Postoperative Complications
Preanesthetic Medication

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.