PMID: 11902975Mar 21, 2002Paper

Sodium copper chlorophyllin: in vitro digestive stability and accumulation by Caco-2 human intestinal cells

Journal of Agricultural and Food Chemistry
Mario G FerruzziSteven J Schwartz

Abstract

Sodium copper chlorophyllin (SCC), a mixture of water-soluble chlorophyll derivatives, is used as both a food colorant and a common dietary supplement. Although the potential antimutagenic and antioxidant properties of this commercial preparation have been demonstrated, limited information is available on its digestion and absorption by humans. Stability of SCC was examined during simulated gastric and small intestinal digestion. Three preparations were subjected to in vitro digestion: SCC in water, SCC in water + 10% corn oil, and SCC in applesauce. SCC components from raw material preparations and in digested samples were analyzed by C(18) HPLC with photodiode array detection. Cu(II)chlorin e(4), the major chlorin component of SCC, was relatively stable during simulated digestion. In contrast, greater than 90% of Cu(II)chlorin e(6) was degraded to undetermined products during digestion. Recovery of Cu(II)chlorin e(6) after digestion was increased by incorporation of SCC into applesauce, suggesting a protective role of the inclusion matrix for stabilization of labile SCC components. Accumulation of SCC derivatives was investigated by using differentiated cultures of the TC7 clone of the Caco-2 human intestinal cell line. Cellu...Continue Reading

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Citations

May 8, 2003·Journal of Toxicology. Clinical Toxicology·Daniel L Sudakin
Dec 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anne LagerqvistDag Jenssen
Dec 11, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michael T SimonichGeorge S Bailey
Jun 21, 2007·Applied Optics·Yugo Nosaka, Eiji Tokunaga
Nov 21, 2007·Journal of Colloid and Interface Science·Paul G House, Cheryl S Schnitzer
Jun 26, 2008·Journal of Food Science·R E Nelson, M G Ferruzzi
Jun 13, 2015·Applied Microbiology and Biotechnology·Viola StrompfováAndrea Lauková
Jul 19, 2011·Mutation Research·Juliana Mara SerpeloniLusânia Maria Greggi Antunes
Oct 1, 2016·International Journal of Molecular Sciences·Małgorzata NormanTeofil Jesionowski
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isabel VieraMaría Roca
Jul 4, 2013·Human & Experimental Toxicology·J M SerpeloniL M G Antunes
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewa Janik-ZabrotowiczKonrad Terpiłowski
Sep 2, 2008·Journal of Agricultural and Food Chemistry·Lourdes Gallardo-GuerreroM Isabel Mínguez-Mosquera
Jul 31, 2021·Journal of Agricultural and Food Chemistry·Isabel VieraMaría Roca
Jul 3, 2021·Macromolecular Bioscience·Carlotta PucciGianni Ciofani
Sep 1, 2005·Journal of Agricultural and Food Chemistry·Mario G Ferruzzi, Steven J Schwartz
Apr 6, 2021·The Indian Journal of Medical Research·M Vishnu Vardhana RaoNeha Yadav

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