Abstract
We investigated the effect of sodium cromoglycate (SCG), delivered as a pressurised aerosol, in a dose of 2 or 4 mg in 15 patients known to have exercise-induced asthma (EIA). All patients had a fall in peak expiratory flow rate (PEFR) greater than 20% of the pre-exercise level following placebo (Range 21.1 to 74.7%). When an identical exercise test was performed after 2 mg of SCG aerosol, nine of the 15 patients had falls in PEFR less than 50% of the value observed on placebo. Of the remaining six patients, four had greater than 50% protection afforded by 4 mg of SCG. Of the 15 patients, 12 had falls in PEFR less than 11% after either 2 or 4 mg of SCG aerosol. The dose of aerosol SCG required to inhibit EIA is only 10 to 20% of that delivered by conventional spinhaler. The apparent superiority of the pressurised aerosol may be due to its site of deposition in the airways.
References
Dec 1, 1979·The Journal of Allergy and Clinical Immunology·S AndersonD A Lindsay
Feb 1, 1977·The Journal of Clinical Investigation·R PattersonT J Kehoe
Oct 27, 1979·British Medical Journal·J T Chung, R S Jones
Oct 1, 1977·British Journal of Pharmacology·D M Jackson, I M Richards
Feb 1, 1974·Clinical Science and Molecular Medicine·S GodfreyJ H Bell
Sep 1, 1973·Thorax·M SilvermanS Godfrey
Jun 1, 1972·Clinical Allergy·M Silverman, M Turner-Warwick
Jan 1, 1970·British Journal of Diseases of the Chest·S GodfreyJ R Nairn
Dec 3, 1967·Nature·J S Cox
Jan 3, 1981·Lancet·M G HarriesT S Orr
Apr 1, 1981·Thorax·S D AndersonL Ferris
Mar 1, 1980·The American Review of Respiratory Disease·G SmithR Bone
Sep 1, 1981·Clinical Allergy·S Y So, D Y Yu
Apr 1, 1982·The Journal of Clinical Investigation·T H LeeA B Kay
Citations
Jan 1, 1985·Thorax·W M TullettK R Patel
Jun 2, 2004·Paediatric Drugs·Sandra D Anderson, John D Brannan
Jan 22, 2005·Treatments in Respiratory Medicine·Sandra D Anderson
Jul 1, 1985·British Journal of Clinical Pharmacology·J BlackC Salome
Jul 1, 1983·Allergy·S D Anderson
Sep 1, 1986·The Journal of Allergy and Clinical Immunology·E F JuniperF E Hargreave
Aug 1, 1996·Respiratory Medicine·S T Holgate
May 1, 1988·Allergy·E SvenoniusP Ekberg
Jul 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Edwards
Apr 19, 2002·Paediatric Drugs·John Massie
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Johannes C van der WoudenFrancine Ducharme
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C K Naspitz
Jan 1, 1987·Drug Intelligence & Clinical Pharmacy·S Murphy, H W Kelly
Feb 1, 1997·Current Problems in Pediatrics·C Randolph