Sodium Cromoglycate Prevents Exacerbation of IgE-Mediated Food-Allergic Reaction Induced by Aspirin in a Rat Model of Egg Allergy

International Archives of Allergy and Immunology
Tomoharu Yokooji, Hiroaki Matsuo

Abstract

Aspirin (ASP)-facilitated absorption of ingested allergens is considered an exacerbating factor in the development of food allergy. Sodium cromoglycate (SCG) is used for the treatment of atopic dermatitis with food allergy, but the efficacy of SCG in ASP-exacerbated food-allergy reactions is unclear. In this study, we evaluated the effect of SCG on ASP-exacerbated food-allergic reactions, as well as allergen absorption, in egg-allergic model rats. Plasma concentrations of ovalbumin (OVA) and fluorescein isothiocyanate-labeled dextran (FD-40), a marker for nonspecific-absorption pathways, were measured after oral administration of mixtures of OVA and FD-40 in OVA-unsensitized and OVA-sensitized rats. IgE-mediated allergic reactions were evaluated by measuring changes in rectal temperature and Evans blue dye (EBD) extravasation in the intestine and liver after oral challenge with OVA. The effects of ASP and SCG on such absorption and allergic reactions were also evaluated kinetically. In OVA-sensitized rats, plasma concentrations of OVA and FD-40 were significantly higher than those in unsensitized rats after oral administration. ASP increased the intestinal absorption of OVA and FD-40 via the paracellular pathway, and a lower re...Continue Reading

Citations

Jan 29, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Zahra GhafouriGholamreza Houshmand
Dec 6, 2019·PloS One·Takahiro FukushimaHiroaki Matsuo
Nov 13, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Katherine D'Astous-GauthierPhilippe Bégin
Mar 9, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Richard L WassermanMarcus Shaker

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