Sodium cromoglycate therapy in IgA nephropathy: a preliminary short-term trial

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M SatoS Koshikawa

Abstract

Sodium cromoglycate (SCG), an antiallergic agent, is an effective drug in an experimental model for IgA nephropathy. The present report concerns a preliminary trial of patients with IgA nephropathy and proteinuria (greater than 1.0 g/d), which was conducted to determine the therapeutic value of SCG. Thirty patients were divided into two groups: one group (n = 15) was given oral SCG (1,200 mg/d) for 16 weeks after an observation of 4 weeks (SCG group), and the other group (n = 15) was observed without the changes of prescription (control group). No fluctuations were noted in proteinuria during the observation period in both groups. Proteinuria in the SCG group slowly decreased throughout the time course; however, a significant reduction was observed at 16 weeks as compared with that of the control group. On the other hand, no significant changes were noted in creatinine clearance (Ccr), serum albumin (s-alb), serum IgA (s-IgA), and IgA-CIC between groups. Five of 15 patients, designated "responders", showed a reduction in proteinuria of more than 50% of the pre-value (average value of observations period). The responder and nonresponder groups were comparable in clinical and histopathological data at the beginning of the trial. ...Continue Reading

References

Nov 1, 1979·The Journal of Experimental Medicine·A RifaiE M Ayoub
Mar 1, 1977·Clinical Allergy·A DannaeusS G Johansson
Jan 1, 1989·Nephron·H KojimaS Koshikawa
Nov 7, 1987·British Medical Journal·K N LaiJ Vallance-Owen
Sep 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y TominoY Nomoto
Feb 1, 1983·The Journal of Experimental Medicine·S N EmancipatorM E Lamm

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Citations

Dec 31, 2015·Nature Reviews. Nephrology·Jürgen Floege, John Feehally
Apr 9, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rosanna Coppo
Mar 18, 2011·The Cochrane Database of Systematic Reviews·Sharon ReidGiovanni Fm Strippoli

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