Sodium cromoglycate, verapamil and nicardipine antagonism to leukotriene D4 bronchoconstriction

British Journal of Pharmacology
C AdvenierA Renier

Abstract

1--The effects of nicardipine, verapamil and sodium cromoglycate (SCG) on the increase in pulmonary airway resistance(RAw) and decrease in pulmonary dynamic compliance (CDyn) induced by leukotriene D4 (LTD4) 0.5 micrograms kg-1 and acetylcholine (ACh) 3 micrograms kg-1 were investigated in anaesthetized guinea-pigs. The effects of these three agents on the contractile effects of LTD4 and ACh were tested on isolated tracheal preparations of the guinea-pig. 2--Nicardipine and verapamil (0.3 and 1 mg kg-1), as well as SCG (3 and 10 mg kg-1), partially but significantly inhibited the effects of LTD4 on RAw. Partial inhibition of the effect of LTD4 on CDyn was only observed with verapamil (0.3 and 1 mg kg-1). Nicardipine and verapamil had no effect on ACh-induced bronchoconstriction in vivo. 3--In concentrations higher than 10(-5) M, nicardipine and verapamil inhibited the contractile effects of LTD4 and ACh on guinea-pig isolated trachea. SCG had no effect on this preparation. 4--These results suggest that nicardipine, verapamil and SCG partially reduce the component of bronchoconstriction associated with stimulation of irritant receptors by LTD4. However, the site and mechanism of action of Ca2+-entry antagonists remain uncertain.

References

May 1, 1975·Journal of Applied Physiology·J M Drazen, K F Austen
Apr 1, 1972·British Journal of Pharmacology·C AdvenierJ F Giudicelli
Oct 1, 1973·British Journal of Pharmacology·S R O'Donnell, N Saar
Feb 5, 1982·European Journal of Pharmacology·D W Hay, R M Wadsworth
Sep 1, 1980·British Journal of Pharmacology·M DixonI M Richards
Mar 21, 1981·British Medical Journal·K R Patel
Jun 26, 1982·British Medical Journal·K R Patel, M Al-Shamma
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M DrazenE J Corey
Feb 1, 1958·The American Journal of Physiology·M O AMDUR, J MEAD

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Citations

Oct 28, 1983·European Journal of Pharmacology·J CerrinaP Duroux
Jul 1, 1987·The American Review of Respiratory Disease·C H FantaJ M Drazen
May 1, 1988·Journal of Pharmacological Methods·D W SnyderM M McCarthy
Jan 1, 1987·Current Medical Research and Opinion·A GianottiP Moscatelli
Jul 1, 1988·British Journal of Clinical Pharmacology·L E AyalaR W Fuller
Jan 25, 1985·The American Journal of Cardiology·C H Fanta
Oct 1, 1984·British Journal of Pharmacology·D Raeburn, I W Rodger
Mar 1, 1987·British Journal of Pharmacology·C AdvenierC Scarpignato
Jan 1, 1987·Drug Intelligence & Clinical Pharmacy·S Murphy, H W Kelly
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·C G Löfdahl, P J Barnes
Jul 1, 1984·British Journal of Pharmacology·C AdvenierA Renier
Oct 1, 1988·The American Journal of Physiology·A ZschauerB P Richardson
Jan 13, 1984·Biochemical and Biophysical Research Communications·J B Cheng, R G Townley

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