Sodium current function in adult and aged canine atrial cells

American Journal of Physiology. Heart and Circulatory Physiology
Shigeo BabaPenelope A Boyden

Abstract

The incidence of atrial fibrillation increases with age, but it is unknown whether there are changes in the intrinsic function of Na+ currents in cells of the aged atria. Thus, we studied right (RA) and left (LA) atrial cells from two groups of dogs, adult and aged (>8 yr), to determine the change in Na+ currents with age. In this study all dogs were in normal sinus rhythm. Whole cell voltage clamp techniques were used to compare the Na+ currents in the two cell groups. Immunocytochemical studies were completed for the Na+ channel protein Na(v)1.5 to determine whether there was structural remodeling of this protein with age. In cells from aged animals, we found that Na+ currents are similar to those we measured in adult atria. However, Na+ current (I(Na)) density of the aged atria differed depending on the atrial chamber with LA cell currents being larger than RA cell currents. Thus with age, the difference in I(Na) density between atrial chambers remains. I(Na) kinetic differences between aged and adult cells included a significant acceleration into the inactivated state and an enhanced use-dependent decrease in peak current in aged RA cells. Finally, there is no structural remodeling of the cardiac Na+ channel protein Na(v)1....Continue Reading

References

Jan 5, 2002·Journal of the American College of Cardiology·Prapa KanagaratnamNicholas S Peters
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sebastian K G MaierWilliam A Catterall
Jun 14, 2002·Cardiovascular Research·Evgeny P AnyukhovskyMichael R Rosen
Sep 6, 2002·Journal of Cardiovascular Electrophysiology·Hideki HayashiHrayr S Karagueuzian
Jun 12, 2003·Cardiovascular Research·Wen DunPenelope A Boyden
Aug 17, 2004·The Journal of Physiology·Sandra A JonesMark R Boyett

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Citations

Mar 13, 2009·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Wen Dun, Penelope A Boyden
Apr 25, 2012·Journal of Cardiovascular Pharmacology·Jia LuIra S Cohen
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Vincent Jacquemet, Craig S Henriquez
Jul 12, 2012·Journal of Geriatric Cardiology : JGC·Hon-Chi LeeWin-Kuang Shen
Feb 13, 2013·Cardiology Research and Practice·Rajiv SankaranarayananClifford J Garratt
Jul 11, 2013·Journal of Cellular and Molecular Medicine·Guo-Jun XuJin-xin Li
May 10, 2015·Mechanisms of Ageing and Development·Sandra A Jones, Matthew K Lancaster
Aug 26, 2014·Frontiers in Physiology·Jussi T KoivumäkiWayne R Giles
Sep 15, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yung-Kuo LinYi-Jen Chen
Mar 25, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Candido Cabo
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
Oct 18, 2018·Frontiers in Cardiovascular Medicine·Arie O VerkerkCarol Ann Remme
Apr 23, 2018·Aging Medicine·Qi ChenJie Cheng

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