Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension

Journal of Hypertension
Tatiana KuznetsovaEuropean Project on Genes in Hypertension Investigators

Abstract

Hypertension is a chronic age-related disorder, affecting nearly 20% of all adult Europeans. This disease entails debilitating cardiovascular complications and is the leading cause for drug prescriptions in Europeans older than 50 years. Intensive research over the past two decades has so far failed to identify common genetic polymorphisms with a major impact on blood pressure or associated cardiovascular phenotypes, suggesting that multiple genes each with a minor impact, along with gene-gene and gene-environment interactions, play a role. The European Project on Genes in Hypertension (EPOGH) is a large-scale, family-based study in which participants from seven different populations were phenotyped and genotyped according to standardized procedures. This review article summarizes the initial 5-year findings and puts these observations into perspective against other published studies. The EPOGH demonstrated that phenotype-genotype relations strongly depend on host factors such as gender and lifestyle, in particular salt intake as reflected by the 24-h urinary excretion of sodium. The EPOGH therefore highlights the concept that phenotype-genotype relations can only be studied within a defined ecogenetic context.

References

Nov 23, 1995·The New England Journal of Medicine·L L BronnerJ E Manson
May 1, 1995·American Journal of Hypertension·F VeglioL Chiandussi
Apr 26, 1993·Archives of Internal Medicine·V J Dzau
Jan 1, 1997·Annual Review of Physiology·T Matsusaka, I Ichikawa
Oct 31, 1998·Journal of Hypertension·P HametJ Tremblay
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·H M SiragyR M Carey
Jan 12, 2001·Journal of the American College of Cardiology·R E SchmiederV Regitz-Zagrosek
Feb 24, 2001·Current Opinion in Nephrology and Hypertension·J A DuncanJ A Miller
Mar 10, 2001·Cell·R P LiftonD S Geller
May 25, 2002·European Journal of Biochemistry·Wilhelm Schoner
Nov 28, 2002·European Journal of Heart Failure·Stefan-Martin HerrmannVera Regitz-Zagrosek
Dec 27, 2002·The New England Journal of Medicine·Ania C MuntauAdelbert A Roscher
Mar 20, 2003·European Heart Journal·Jan A StaessenWillem H Birkenhäger
May 16, 2003·Lancet·Jan A StaessenWillem H Birkenhäger
May 24, 2003·Annals of the New York Academy of Sciences·Wilhelm SchonerErnst-Güngther Grünbaum
May 24, 2003·Annals of the New York Academy of Sciences·P FerrariG Bianchi
Jun 27, 2003·Lancet·Stephen B Harrap
Jul 23, 2003·Journal of Hypertension·Ji-Guang WangPaolo Manunta
Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Yoshiyu Takeda
Feb 7, 2004·Human Molecular Genetics·Charles A MeinPatricia B Munroe
Apr 13, 2004·Journal of Hypertension·Tatiana KuznetsovaUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Jul 9, 2004·Hypertension·Katarzyna StolarzUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Oct 20, 2004·Circulation·Tatiana KuznetsovaUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Dec 23, 2004·Journal of Hypertension·Wiktoria WojciechowskaUNKNOWN European Project on Genes in Hypertension (EPOGH) Investigators

❮ Previous
Next ❯

Citations

Mar 18, 2009·Pharmacogenomics·Murielle BochudChin B Eap
Jan 9, 2014·Current Treatment Options in Cardiovascular Medicine·Matthew C Konerman, Scott L Hummel
Jun 14, 2008·The Journal of Clinical Hypertension·John P FormanGary C Curhan
May 22, 2013·American Journal of Hypertension·Roberto SchreiberWilson Nadruz
Oct 13, 2006·Nature Reviews. Genetics·Allen W Cowley
Feb 9, 2008·Hypertension·Megan CoylewrightPamela Ouyang
Jul 14, 2010·Journal of Hypertension·Simon de Denus, Marie-Pierre Dubé
Jan 9, 2009·American Journal of Physiology. Renal Physiology·Hsiang-Hao HsuMartin Johannes Bek
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Edoardo CasigliaAchille C Pessina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.