Sodium fluoride in cardiovascular disorders: A systematic review.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Beatriz Isabel Silva MendesMaria João Vidigal Ferreira

Abstract

18-Fluorine sodium fluoride is a well-known radiotracer used for bone metastasis diagnosis. Its uptake correlation with cardiovascular (CV) risk was primarily suggested in oncological patients. Moreover, as a specific marker of microcalcification, it seems to correlate with CV disease progression and plaque instability. Our purpose was to systematically review clinical studies that characterized the use of this marker in CV conditions. In atherosclerosis, most studies report a positive correlation with the burden of CV risk factors and vascular calcification. A higher uptake was found in culprit plaques/rupture sites in coronary and carotid arteries and it was also linked to high-risk features in histology and intravascular imaging analysis of the plaques. In aortic stenosis, this tracer displayed an increasing uptake with disease severity. Sodium fluoride positron emission tomography is a promising non-invasive technique to identify high-risk plaques, which sets ground to a potential use of this tracer in evaluating atherosclerotic disease progression and degenerative changes in aortic valve stenosis. Nevertheless, there is a need for further prospective evidence that demonstrates this technique's value in predicting clinical ...Continue Reading

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Citations

Sep 19, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Valeria CantoniAlberto Cuocolo
Apr 15, 2020·International Journal of Molecular Sciences·Yujie ShiSiyu Chen
Nov 5, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Li Xin ZhangMatthieu Pelletier-Galarneau
Apr 8, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·João Borges-RosaMaria João Ferreira

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