PMID: 2500593Jun 1, 1989Paper

Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: a proposed mechanism

Mutation Research
M J AardemaR A LeBoeuf

Abstract

In an attempt to clarify the controversy about sodium fluoride (NaF) clastogenicity, the induction of chromosome aberrations in Chinese hamster ovary cells (CHO) by NaF was investigated. Following a protocol used for screening chemicals for clastogenic activity, significant increases of aberrant cells were observed when cells were exposed to NaF for 4 h and harvested 8 h later. Cell-cycle kinetic studies demonstrated most cells were exposed in G2 of the cell cycle. Smaller increases in aberrant cells were observed when cells were harvested 20 h later (most cells were exposed in G1/S). The sensitivity of G2 cells to NaF was investigated further, along with the induction of aberrations at low doses. The results indicated that G2 cells are sensitive to NaF and the percent of aberrant cells increased with dose and length of exposure. With a 3-h exposure until harvest, no statistically significant increase in aberrant cells was observed at doses below 10 micrograms/ml NaF. These data are consistent with a threshold for NaF-induced clastogenicity around 10 micrograms/ml, as has been proposed previously (Scott and Roberts, 1987). It thus may be predicted that clastogenic effects would not occur in humans exposed to the levels of fluor...Continue Reading

References

Aug 1, 1977·Computers and Biomedical Research, an International Journal·D G ThomasJ J Gart
Sep 20, 1976·Biochimica Et Biophysica Acta·R A WaltersC E Hildebrand
Apr 1, 1986·Mutation Research·R C MooreM A Bender
Mar 1, 1987·Mutation Research·W J CasparyA Brown
Mar 1, 1988·Mutation Research·Y M LiG K Stookey
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R T SchimkeR N Johnston
May 1, 1987·Journal of Dental Research·J Ekstrand
Nov 1, 1987·Mutation Research·Y M LiG K Stookey
Oct 1, 1974·Archives of Environmental Health·G Jagiello, J S Lin
Apr 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·P BjerleG Michaelson
Jun 1, 1981·Cancer Genetics and Cytogenetics·S Sutou
Dec 1, 1980·Koku Eisei Gakkai zasshi·A Matsuda
Apr 27, 1981·Biochimica Et Biophysica Acta·J B SchvartzmanJ Van't Hof
Nov 1, 1987·Journal of Dental Research·Y LiG K Stookey
Sep 1, 1959·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S H REVELL

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Citations

Jan 1, 1994·Archives of Environmental Contamination and Toxicology·A M Khalil, A A Da'dara
Sep 1, 1995·Mutation Research·M J Aardema, T Tsutsui
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T TsutsuiJ C Barrett
Jun 26, 2001·Mutation Research·J J ClarkeD Jacobson-Kram
May 1, 1991·Medical Hypotheses·P R Sutton
Dec 22, 1999·Human & Experimental Toxicology·M RefsnesP E Schwarze
Dec 29, 2004·Brazilian Oral Research·Daniel Araki RibeiroDaisy Maria Fávero Salvadori
Aug 23, 2006·Brazilian Dental Journal·Daniel Araki RibeiroDaisy Maria Fávero Salvadori
Dec 15, 2010·Journal of Applied Toxicology : JAT·Santosh PodderAnindita Chakraborty
Jan 1, 1996·Environmental and Molecular Mutagenesis·D PutmanD Jacobson-Kram
Oct 3, 2020·Toxicological Research·V P VolobaevA V Larionov
Jan 1, 1993·Environmental and Molecular Mutagenesis·E ZeigerK L Witt
Jul 9, 1991·International Journal of Cancer. Journal International Du Cancer·J R BucherJ K Haseman
Feb 23, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hemlata Tiwari, Mandava V Rao

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