Sodium-fluoride PET-CT for the non-invasive evaluation of coronary plaques in symptomatic patients with coronary artery disease: a cross-correlation study with intravascular ultrasound

European Journal of Nuclear Medicine and Molecular Imaging
Li LiSijin Li

Abstract

The aim of this study was to evaluate the 18F-sodium fluoride (18F-NaF) coronary uptake compared to coronary intravascular ultrasound (IVUS) in patients with symptomatic coronary artery disease. 18F-NaF PET enables the assessment of vascular osteogenesis by interaction with surface hydroxyapatite, while IVUS enables both identification and quantification of intra-plaque components. Forty-four patients with symptomatic coronary artery disease were included in this prospective controlled trial, 32 of them (30 patients with unstable angina and 2 patients with stable angina), representing the final study cohort, got additional IVUS. All patients underwent cardiac 18F-NaF PET/CT and IVUS within 2 days. 18F-NaF maximum tissue-to-blood ratios (TBRmax) were calculated for 69 coronary plaques and correlated with IVUS plaque classification. Significantly increased 18F-NaF uptake ratios were observed in fibrocalcific lesions (meanTBRmax = 1.42 ± 0.28), thin-cap atheroma with spotty calcifications (meanTBRmax = 1.32 ± 0.23), and thick-cap mixed atheroma (meanTBRmax = 1.28 ± 0.38), while fibrotic plaques showed no increased uptake (meanTBRmax = 0.96 ± 0.18). The 18F-NaF uptake ratio was consistently higher in atherosclerotic lesions with se...Continue Reading

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Citations

Jan 24, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Vlad G ZahaDarren K McGuire
Nov 15, 2019·Journal of Atherosclerosis and Thrombosis·Teresa InfanteClaudio Napoli
Mar 21, 2020·Annals of Nuclear Medicine·Stavroula GiannakouPanagiotis Georgoulias
Oct 3, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Takehiro NakaharaH William Strauss
Nov 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Poul F Høilund-CarlsenOke Gerke
Sep 25, 2019·Diagnostics·Federico VancheriMichael Y Henein
Jan 4, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Toshiro KitagawaYasuki Kihara
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Nov 5, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Laura MechtouffNorbert Nighoghossian

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