Sodium-glucose co-transporter-2 inhibitor cardiovascular outcome trials and generalizability to English primary care.

Diabetic Medicine : a Journal of the British Diabetic Association
William HintonSimon de Lusignan

Abstract

To identify people in English primary care with equivalent cardiovascular risk to participants in the sodium-glucose co-transporter-2 inhibitor (SGLT-2i) cardiovascular outcome trials (CVOTs). A secondary objective was to report the usage of SGLT-2is. Cross-sectional analysis of people registered with participating practices in the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) network on the 31 December 2016. We derived: (1) proportions of the primary care population eligible for inclusion in each SGLT-2i CVOT (CANVAS, DECLARE, EMPA-REG and VERTIS); (2) characteristics of the eligible population compared with trial participants (demographics, disease duration and vascular risk); and (3) differences within the eligible population prescribed SGLT-2is. The proportions of people with type 2 diabetes (N = 84 394) meeting the inclusion criteria for each CVOT were: DECLARE 27% [95% confidence interval (CI) 26.5-27.1]; CANVAS 17% (16.6-17.1); VERTIS 7% (7.1-7.4); and EMPA-REG 7% (6.5-6.8). Primary care populations fulfilling inclusion criteria were 5-8 years older than trial cohorts, and <10% with inclusion criteria of each trial were prescribed an SGLT-2i; a greater proportion were men, and of wh...Continue Reading

References

Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
Jun 14, 2016·The New England Journal of Medicine·Steven P MarsoUNKNOWN LEADER Trial Investigators
Sep 17, 2016·The New England Journal of Medicine·Steven P MarsoUNKNOWN SUSTAIN-6 Investigators
Mar 1, 2017·Diabetes, Obesity & Metabolism·Bruce NealUNKNOWN CANVAS Program collaborative group
Mar 23, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Andrew McGovernSimon de Lusignan
Jun 13, 2017·The New England Journal of Medicine·Bruce NealUNKNOWN CANVAS Program Collaborative Group
Oct 1, 2017·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Simon de LusignanDouglas Fleming
Nov 13, 2018·The New England Journal of Medicine·Stephen D WiviottUNKNOWN DECLARE–TIMI 58 Investigators
May 2, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·William HintonSimon de Lusignan

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Citations

Sep 10, 2021·Cardiovascular Diabetology·Lisanne C A SmidtUNKNOWN UCC-SMART Study Group

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Software Mentioned

REG
DISCOVER
DECLARE
CANVAS

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