PMID: 9170003May 1, 1997Paper

Sodium intake regulates renin gene expression differently in the hypothalamus and kidney of rats

Journal of Hypertension
M NishimuraM Yoshimura

Abstract

To elucidate the different effects of sodium intake on renin messenger RNA (mRNA) in the hypothalamus and the kidney and to investigate the role of hypothalamic renin in sodium-induced hypertension. We investigated the expression of the renin gene in the hypothalamus and the kidney of rats with altered sodium intake and those administered either deoxycorticosterone acetate (DOCA) or sodium. Diets containing a high (8% NaCl), normal (2% NaCl), or low (0.2% NaCl) amount of sodium were administered to 12-week-old male Wistar rats for 10 days or 8 weeks before the rats were killed. Male Wistar rats administered either DOCA or 1% NaCl were killed 2 weeks (during the prehypertensive stage) or 6 weeks (during the hypertensive stage) after the start of treatment. The hypothalamus and kidneys were excised for extraction of total RNA. Competitive polymerase chain reaction of renin mRNA and deletion-mutated renin RNA was performed, and the renin mRNA concentration was calculated. A high sodium intake for 10 days increased the renin mRNA in the hypothalamus; the hypothalamic renin mRNA had not been suppressed after 8 weeks of a high sodium intake despite the lowering in renal renin mRNA. Renin mRNA levels in the hypothalamus were not suppr...Continue Reading

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Citations

Jan 5, 2014·International Journal of Hypertension·Juan J Bolívar
May 17, 2005·Journal of Hypertension·Masato NishimuraManabu Yoshimura
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Catherine IngertJean-Louis Imbs
Jul 5, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jun Ming WangFrans H H Leenen
Jan 7, 2017·Clinical Science·Sinan Khor, Dongsheng Cai
May 8, 1999·The American Journal of Physiology·M NishimuraM Yoshimura

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