Sodium kinetics across dialysis membranes

Nephron
F LocatelliC Pozzi

Abstract

The kinetics of sodium across dialysis membranes were studied during diffusion and during convection utilizing cuprophan and cellulose hydrate membranes. During diffusion the changes in plasma water sodium concentration are correlated to the sodium concentration gradient between plasma water and dialysate but an increase also occurs when the gradient is annulled, due to the Donnan effect. During convection the plasma water sodium concentration increases during the passage through the dialyzer and the ultrafiltrate sodium concentration is significantly lower than the plasma water sodium concentration; this is due to the fact that the plasma proteins, as anions unable to cross the membrane, affect the kinetics of the sodium cations. Therefore, during diffusion the kinetics of sodium are mainly affected by the sodium concentration gradient and by the plasma protein concentration, while during convection the plasma protein concentration is the main factor affecting the kinetics of sodium.

Citations

Oct 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M FischbachJ Geisert
Aug 11, 2000·Kidney International. Supplement·M J Flanigan
Sep 13, 2003·Seminars in Dialysis·Jeroen P KoomanFrancesco Locatelli
Jun 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rebecca J SucklingGraham A MacGregor
Feb 1, 1986·Artificial Organs·S Ringoir, R Vanholder
Feb 5, 2014·Journal of Nephrology·Shailesh BihariAndrew D Bersten
Sep 1, 1991·Kidney International·L A PedriniF Locatelli
Jan 10, 2017·Seminars in Dialysis·Jennifer E Flythe, Finnian R Mc Causland
Jan 16, 2019·The Cochrane Database of Systematic Reviews·Joanna L DunlopMark R Marshall
Jan 1, 2000·Hemodialysis International·Bernard CharraGuy Laurent
Jan 1, 2001·Hemodialysis International·Bernard CharraCharles Chazot
Oct 17, 2020·Seminars in Dialysis·Mohammad Tinawi, Bahar Bastani

Related Concepts

Cuprammonium cellulose
Body Water
Alphacel
Diffusion
Hemodialysis
Membranes, Artificial
Fresh Frozen Plasma
Sodium
Ultrafiltration

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