Sodium levels during hospitalization with acute myocardial infarction are markers of in-hospital mortality: Soroka acute myocardial infarction II (SAMI-II) project

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Ygal PlakhtArthur Shiyovich

Abstract

Abnormalities in sodium homeostasis are common in hospitalized patients. Hyponatremia upon admission is a poor prognostic marker in acute myocardial infarction (AMI) patients. However, little is known about the association between changes in sodium levels and in-hospital mortality. We delineated changes in sodium levels and studied the association of such changes with in-hospital mortality of AMI patients. Retrospective analysis of AMI patients hospitalized for > 6 days. Sodium levels throughout the 6-day post-admission were divided into five equally sized groups (quintiles = Q) and thereafter categorized as follows: Q1 (< 135 mEq/L), Q2-Q4 (135-140 mEq/L, reference group), and Q5 (≥141 mEq/L). in-hospital mortality. A total of 8306 patients (10,416 admissions) were included (mean age 67.8 ± 14.0 years, 33.4% women, 45.5% STEMI). In-hospital mortality was 6.6%. Q1 and Q5 upon admission were both related to higher risk for in-hospital mortality, compared with the reference group (OR 1.47 and OR 1.33, respectively, p < 0.001 each). Q1 was more frequent in non-survivors throughout the entire study period, while the prevalence of Q5 levels was similar in survivors and non-survivors upon admission carrying increasing mortality risk ...Continue Reading

References

Feb 1, 1991·Clinical Cardiology·M MouallemZ Farfel
Dec 8, 1983·The New England Journal of Medicine·M J BrownM B Murphy
Nov 1, 1993·American Heart Journal·A SigurdssonK Swedberg
Jan 15, 1996·Annals of Internal Medicine·P M PalevskyA Greenberg
Aug 19, 1999·The New England Journal of Medicine·R W Schrier, W T Abraham
May 29, 2000·The New England Journal of Medicine·H J Adrogué, N E Madias
Jun 27, 2003·Journal of Cardiovascular Pharmacology·Xue-Dong YangXue Li
Aug 17, 2004·The American Journal of Medicine·Alexander GoldbergDoron Aronson
Apr 12, 2006·Archives of Internal Medicine·Alexander GoldbergDoron Aronson
Jul 31, 2007·The American Journal of Cardiology·Ish SinglaAli F Sonel
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Nov 26, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Štěpán HavránekAleš Linhart
Feb 26, 2011·Cell Calcium·Shahrzad MovafaghMartin Morad
May 28, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuko TadaShin-Ichi Momomura
Jan 8, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ewout J Hoorn, Robert Zietse
May 9, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Waqas QureshiZaid Alirhayim
May 24, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dariush AfzaliPia Lebiedz
Feb 5, 2014·International Journal of Cardiology·Arthur ShiyovichYgal Plakht
Aug 25, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S G WannametheeP Whincup
Oct 28, 2016·Drugs -- Real World Outcomes·Richard J WoodmanArduino A Mangoni
Feb 10, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Amr AbdinHolger Thiele

❮ Previous
Next ❯

Citations

Feb 3, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jaroslaw ZalewskiAnetta Undas
Apr 8, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Mark LipphardtManuel Wallbach
Apr 25, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Pieter MartensPatrick Rossignol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.