Sodium-lithium countertransport is associated with insulin resistance and urinary albumin excretion in young African-Americans

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
B FalknerH Kushner

Abstract

Increased activity of the sodium transporter, sodium-lithium countertransport (SLC), is reported in hypertensive white patients with evidence of cardiac and renal injury. The purpose of this study was to determine whether increased SLC activity detects risk for nephropathy or vascular disease in nondiabetic, young adult African-Americans. We examined 85 African-Americans aged 25 to 33 years with measurement of blood pressure, an oral glucose tolerance test to measure insulin response to glucose challenge, and an insulin clamp for insulin sensitivity (M). Fasting plasma lipids were measured, and the Vmax and Km for Na+ were assayed on red blood cells. Urinary albumin excretion (UAE) was measured on timed collections. There was a statistically significant correlation of the Vmax for SLC with M (r = -0.26, P = 0.02) and with UAE (r = 0.25, P = 0.02). The Km for Na+ to activate SLC was also elevated in the subgroup of subjects with elevated Vmax of SLC. There was no significant correlation of SLC with blood pressure in bivariate analysis. Step-wise multiple linear regression analysis of all variables on the Vmax SLC demonstrated that plasma triglyceride, UAE, body mass index, systolic blood pressure, M, and fasting insulin were ste...Continue Reading

References

Oct 1, 1992·Journal of the American Society of Nephrology : JASN·G C Viberti, K Earle
Oct 1, 1992·Journal of the American Society of Nephrology : JASN·M CanessaL M Laffel
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·I ZavaroniG M Reaven
Jun 1, 1989·American Journal of Hypertension·A L SwislockiG M Reaven
Jan 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P H Bennett
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Jan 21, 1988·The New England Journal of Medicine·A S KrolewskiL I Rand
May 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·R J JarrettT J Murrells
Sep 1, 1983·American Journal of Epidemiology·R R WilliamsK O Ash
Feb 9, 1984·The New England Journal of Medicine·C E Mogensen
Jan 1, 1984·Hypertension·A B WederS Julius
May 1, 1982·The American Journal of Clinical Nutrition·S B HeymsfieldJ Smith
Apr 3, 1980·The New England Journal of Medicine·M CanessaD C Tosteson
Sep 1, 1994·Current Opinion in Nephrology and Hypertension·M Canessa
Jul 1, 1993·Kidney International·R MangiliG Pozza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.