Sodium Nitrite Prevents both Reductions in Circulating Nitric Oxide and Hypertension in 7-Day Lead-Treated Rats

Basic & Clinical Pharmacology & Toxicology
Victor Hugo Gonçalves-RizziCarlos A Dias-Junior

Abstract

Hypotensive effects of oral sodium nitrite have been reported as alternative sources of nitric oxide (NO) formation in animals and human beings. Reductions in NO bioavailability were observed in lead-induced hypertension. However, no previous study has examined whether a single daily dose of sodium nitrite prevents the reductions in the NO bioavailability in lead-induced hypertension. Then, we expanded previous reports and evaluated the effects of sodium nitrite in 7-day lead-treated rats. Wistar rats were divided into four experimental groups: Pb+sodium nitrite group received intraperitoneally (i.p.) 1st dose 8 µg/100 g of lead acetate and a subsequent dose of 0.1 µg/100 g, and daily treatment with sodium nitrite (45 mg/kg/day) or water (Pb group) by gavage for 7 days; Sodium nitrite group received i.p. 1st dose 8 µg/100 g of sodium acetate and a subsequent dose of 0.1 µg/100 g, and daily treatment with sodium nitrite (45 mg/kg/day) or water (saline group) by gavage for 7 days. Similar and higher whole-blood lead levels (11.5 ± 1.2 and 13.2 ± 0.7 µg/dL) were found in lead-exposed rats treated with either water or sodium nitrite (Pb or Pb+sodium nitrite, respectively; both p  <  0.05 versus control groups). We found lower NO ma...Continue Reading

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Citations

Jan 17, 2016·Environmental Toxicology and Pharmacology·Joao Leandro ChaguriCarlos Alan Dias-Junior
Sep 14, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Jose Sergio Possomato-VieiraCarlos A Dias-Junior
Dec 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ming-Lin ZhuCarlos A Dias-Junior
Nov 13, 2017·Cardiovascular Drugs and Therapy·Roy O MathewMandeep S Sidhu
Oct 28, 2019·Journal of Cardiovascular Pharmacology·Wei Chih LingDharmani Devi Murugan
May 24, 2018·BioMed Research International·José Sérgio Possomato-VieiraCarlos A Dias-Junior

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