Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults

Experimental Physiology
Jenna M SchulzJ K Shoemaker

Abstract

What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is the main finding and its importance? This study demonstrated that vasodilatation occurs in the right middle cerebral artery in response to exogenous nitric oxide. However, blood velocity decreased and, therefore, overall cerebral blood flow remained unchanged. This study provides new insight into the role of nitric oxide in cerebral blood flow control. Recent evidence indicates that basal cerebral conduit vessels dilate with hypercapnia, with a nitric oxide (NO) mechanism explaining one way in which parenchymal cerebral arterioles dilate. However, whether NO affects basal cerebral artery dilatation remains unknown. This study quantified the effect of an exogenous NO donor [sodium nitroglycerin (NTG); 0.4 mg sublingual spray] on the right middle cerebral artery (rMCA) cross-sectional area (CSA), blood velocity and overall blood flow. Measures of vessel CSA (7 T magnetic resonance imaging) and MCA blood velocity (transcranial Doppler ultrasound) were made at baseline (BL) and after exogenous NTG or placebo (PLO) administration in you...Continue Reading

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Citations

May 14, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine L JarrettRussell S Richardson
Jul 1, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kate N ThomasMartin Necas

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