PMID: 9436551Jan 22, 1998Paper

Sodium nitroprusside exacerbates myocardial ischemia-reperfusion injury

The Annals of Thoracic Surgery
J T CopeI L Kron

Abstract

The role of nitric oxide in myocardial ischemia-reperfusion is controversial. Although many studies claim that nitric oxide ameliorates reperfusion injury, others suggest that it exacerbates such injury, possibly through peroxynitrite production. These discordant results may be attributable to a dose-dependent phenomenon. Isolated rabbit hearts sustained sequential periods of blood perfusion (20 minutes), warm ischemia (30 minutes), and reperfusion (20 minutes). During reperfusion, four groups underwent intracoronary infusion of saline solution (n = 6), or the nitric oxide donor sodium nitroprusside (100 nm/min [SNP100, n = 6], 1 nmol x L(-1)/min(-1) [SNP1, n = 6], or 0.01 nmol x L(-1) x min(-1) [SNP0.01]). Left ventricular-developed pressure and oxygen consumption were measured after preischemic perfusion and reperfusion. Levels of myocardial nitrotyrosine, a marker for peroxynitrite, were measured after reperfusion with an immunoradiochemical assay. Postischemic-developed pressure and myocardial oxygen consumption were significantly higher in the saline group than all nitroprusside-reperfused groups (p < 0.01 for both parameters). However, there were no differences in either parameter between SNP100, SNP1, or SNP0.01. Nitroty...Continue Reading

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Citations

Sep 18, 2001·Heart·R D Rakhit, M S Marber
Nov 9, 2002·Autonomic & Autacoid Pharmacology·Kwang Joon KimUy Dong Sohn
Jun 15, 2011·Pharmacology & Therapeutics·Michelle J ButlerStephen J Duffy
Oct 2, 2012·International Journal of Cardiology·Charalampos N PierrakosJohn N Nanas
Dec 29, 2009·Journal of Molecular and Cellular Cardiology·Hanrui Zhang, Cuihua Zhang
Jan 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ryuji HataishiMarielle Scherrer-Crosbie
May 18, 1999·The American Journal of Physiology·L AgullóJ Soler-Soler
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R K KudejS F Vatner

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