Sodium nitroprusside: low price and safe drug to control BP during thrombolysis in AIS

Arquivos de neuro-psiquiatria
Jessyca L KoslykMarcos C Lange

Abstract

This study analyzes the use of sodium nitroprusside (SN) as an option to reduce blood pressure (BP) below 180/105 mmHg during the management of acute ischemic stroke (AIS) in patients submitted to intravenous thrombolysis.Method The sample was composed by 60 patients who had AIS and were submitted to intravenous rtPA, split in two groups: half in the control group (CG) with BP < 180/105 mmHg and half in SN group with BP > 180/105 mmHg. Outcome variables were any hemorrhagic transformation (HT); the presence of symptomatic HT, National Institute of Health Stroke Scale (NIHSS) after 24 hours of treatment; the independence on discharge and death until three months after stroke onset.Results There were no statistical differences between both groups to any of the outcome variables analyzed.Conclusion The SN might be safe for BP control during thrombolysis to AIS.

References

Jan 1, 1981·Acta neurochirurgica·C AnileG F Rossi
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R P WhiteH S Markus
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Jo Leonardi-BeeUNKNOWN IST Collaborative Group
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·H S Markus
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Heinrich P MattleGerhard Schroth
Apr 9, 2008·Lancet Neurology·Craig S AndersonUNKNOWN INTERACT Investigators
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Apr 30, 2011·Stroke; a Journal of Cerebral Circulation·Lars KellertPeter A Ringleb
Nov 24, 2012·Arquivos de neuro-psiquiatria·Sheila Cristina Ouriques MartinsUNKNOWN Executive Committee from the Brazilian Stroke Society and the Scientific Department in Cerebrovascular Diseases of the Brazi
Nov 19, 2013·JAMA : the Journal of the American Medical Association·Jiang HeUNKNOWN CATIS Investigators
Aug 19, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Craig S AndersonUNKNOWN ENCHANTED Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.