Sodium nitroprusside treatment of severe arterial hypertension in children.

The Journal of Pediatrics
G Gordillo-PaniaguaE Valdez-Bolaños

Abstract

Severe arterial hypertension in children constitutes a high-risk situation requiring rapid and effective therapy. We have assessed the clinical value of sodium nitroprusside as a rapidly acting antihypertensive agent. Twenty children admitted with hypertensive crises of renal origin were treated with intravenous infusion of sodium nitroprusside at an average rate of 1.4 mug/kg/min. Desired levels of blood pressure were reached in all patients within one to 20 minutes. Rapid improvement of cardiac failure was observed in all patients, and neurologic signs of distress disappeared in 16 of the 20 children within 24 to 48 hours of treatment, permitting substitution of oral medication. One patient died of cerebral hemorrhage without improvement of encephalopathy. There were no undesirable effects of therapy or deterioration of renal function in any patient.

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Citations

Jul 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jayanthi Chandar, Gastón Zilleruelo
Jul 3, 2002·Current Treatment Options in Cardiovascular Medicine·Craig W. Belsha
Apr 1, 2005·Current Opinion in Pediatrics·Hiren P Patel, Mark Mitsnefes
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Sep 1, 1992·Archives of Disease in Childhood·J E DealM J Dillon
Sep 6, 2011·Paediatric Drugs·Christopher A Thomas
Aug 12, 2005·The Pediatric Infectious Disease Journal·Alejandro E MaciasSamuel Ponce-de-Leon
Jan 1, 1985·The Journal of Pediatrics·W E BenitzP Sunshine
May 1, 1985·The Journal of Pediatrics·W F Friedman, B L George
Dec 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·R S WilliamsG K Lofland
Jul 1, 1982·Pediatric Annals·L Reisman, R V Selden
Nov 28, 2013·Pharmaceuticals·Joseph D TobiasSergio D Bergese
Aug 1, 1976·Australian and New Zealand Journal of Medicine·R Zacest
Oct 3, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomáš SeemanMark Mitsnefes
Sep 12, 2020·Pediatric Cardiology·Joseph D TobiasCatherine D Krawczeski

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