Sodium oxybate for cataplexy

The Annals of Pharmacotherapy
Michael D LemonDebra K Farver

Abstract

To review the pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, precautions, dosing recommendations, and patient counseling of sodium oxybate for the treatment of cataplexy in patients with narcolepsy. OVID and PubMed databases were searched (1966-January 2006) using the key words sodium oxybate, gamma-hydroxybutyrate, narcolepsy, and cataplexy. Only English-language articles were selected. All information on sodium oxybate related to narcolepsy and cataplexy was considered. Study selection included human trials evaluating safety and efficacy of sodium oxybate for the treatment of cataplexy. Sodium oxybate is approved by the Food and Drug Administration for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy. In placebo-controlled trials, sodium oxybate demonstrated efficacy in reducing the number of cataplexy attacks. The dosing regimen includes a split dose given at bedtime and 2.5-4 hours later due to its short elimination half-life. The drug is generally well tolerated, with headache, nausea, dizziness, pain, and somnolence being the most common adverse events. Sodium oxybate is safe and effective for the treatment of cataplexy. Potential disadvantages...Continue Reading

References

Feb 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R Broughton, M Mamelak
Jan 1, 1996·European Journal of Clinical Pharmacology·S D FerraraP Palatini
May 20, 1998·Ryōikibetsu shōkōgun shirīzu·M MaekawaT Kanno
Sep 12, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Merrill M Mitler, Roza Hayduk
Jan 11, 2003·Journal of Clinical Pharmacology·Lowell A BorgenAllen Lai
Mar 28, 2003·Southern Medical Journal·Neil T Feldman
Oct 4, 2003·Pharmacotherapy·David E Fuller, Carl S Hornfeldt
Mar 23, 2004·Sleep Medicine·UNKNOWN U.S. Xyrem Multicenter Study Group
Apr 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·David E FullerTodd F Anderson
Apr 16, 2004·Journal of Toxicology. Clinical Toxicology·Deborah L Zvosec, Stephen W Smith
Aug 10, 2004·Toxicological Reviews·Asim F Tarabar, Lewis S Nelson
Sep 1, 2004·Sleep Medicine Reviews·William C HoughtonMichael Thorpy
Dec 2, 2004·Expert Opinion on Emerging Drugs·Vivien C Abad, Christian Guilleminault
Mar 11, 2005·Expert Opinion on Pharmacotherapy·Michael J Thorpy
Jul 1, 2005·The New England Journal of Medicine·O Carter Snead, K Michael Gibson

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Citations

Mar 9, 2010·The International Journal of Eating Disorders·Susan L McElroyJames I Hudson
Jan 10, 2012·The American Journal of Drug and Alcohol Abuse·Wesley T LindseyDarrell Childress

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