Sodium pentobarbital-induced cross-tolerance to ethanol is learned in the rat

Pharmacology, Biochemistry, and Behavior
J R WengerS C Woods

Abstract

Initially, rats were trained to walk on a treadmill to avoid footshock. Subsequently, rats given additional practice while pentobarbital-intoxicated became cross-tolerant to ethanol. However, rats given equivalent doses of pentobarbital after practice did not become cross-tolerant, nor did saline-vehicle controls. These results challenge the theories of cross-tolerance which are based exclusively upon cellular adaptations to pharmacological stimulation of drug-responsive neurons. That all of the cross-tolerance measured was attributable to the intoxicated practice suggests that this observed cross-tolerance was mediated by some form of learning.

References

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Citations

May 10, 2000·Behavioural Brain Research·S C Woods, D S Ramsay

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