PMID: 8953473Dec 1, 1996Paper

Sodium pentobarbitone and the suppression of luteinizing hormone pulses in the female rat: the role of hypothermia

Journal of Neuroendocrinology
P H Strutton, C W Coen

Abstract

The role of hypothermia in the suppression of pulsatile luteinizing hormone (LH) release by the barbiturate sodium pentobarbitone has been investigated in ovariectomized rats. Each animal was fitted with an intraperitoneal miniature radio transmitter to monitor core temperature and with an indwelling intravenous and intraperitoneal catheter. During the 6-h sampling period the animal's core temperature was recorded automatically every 5 min and a 25 microliters blood sample was obtained concurrently using an automated system. After the initial 3 h of sampling either the drug or the vehicle was administered via the intraperitoneal cannula from outside the cage, thus ensuring minimal disturbance to the animal. Administration of sodium pentobarbitone (40 mg/kg) at an ambient temperature of 21 degrees C resulted in a significant hypothermia throughout the 3-h post-injection period. During this period there was a significant reduction in mean LH concentration, and in the frequency and amplitude of the LH pulses. When the drug was administered at an ambient temperature of 35 degrees C there was no reduction in core temperature and no significant change in the LH pulse parameters. Vehicle treatment was without significant effect on cor...Continue Reading

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