Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial

Gut and Liver
Hyun Gun KimHyo Jong Kim

Abstract

We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). The SPMC/bisacodyl treatme...Continue Reading

References

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Citations

Jun 22, 2016·Langenbeck's Archives of Surgery·A C A Murray, R P Kiran
May 8, 2020·Current Gastroenterology Reports·Valentine Ongeri Millien, Nabil M Mansour
May 20, 2020·Journal of Gastroenterology and Hepatology·Yusuf Coskun, Ilhami Yuksel
Jun 18, 2019·Therapeutic Advances in Gastroenterology·Lawrence HookeyStuart P Brogadir
Aug 24, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seok Won LeeDong Joon Kim
Nov 30, 2019·Frontiers in Medicine·Goretti HernándezEnrique Quintero
Nov 23, 2017·United European Gastroenterology Journal·Ilvy van LieshoutRené van der Hulst
Jan 12, 2019·World Journal of Gastrointestinal Endoscopy·Rodrigo Silva de Paula RochaEduardo Guimarães Hourneaux de Moura
May 16, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Milou L M van RiswijkPeter D Siersema

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