Sodium polyanethol sulfonate inactivation of aminoglycosides.

Antimicrobial Agents and Chemotherapy
D J KrogstadJ E Davis

Abstract

Sodium polyanethol sulfonate and another polyanion (dextran sulfate) both inhibited aminoglycoside activity in vitro. This effect was not produced by an otherwise similar neutral carbohydrate (dextran) or by neutral detergents (Brij-35, Triton X-100) but was antagonized by an anion-exchange resin (Dowex 1X8-50). We conclude that the inactivation of aminoglycosides by sodium polyanethol sulfonate results from its polyanionic nature and is unrelated to its detergent properties.

References

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Citations

Oct 1, 1986·European Journal of Clinical Microbiology·G Pierce, P R Murray
Jan 17, 2012·The Journal of Molecular Diagnostics : JMD·John F ReganJeanne A Jordan
Mar 8, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mustafa A AlkawashNeal L Schiller
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Nov 1, 1982·Journal of Clinical Microbiology·P R Murray, A C Niles
Nov 18, 1998·Journal of Clinical Microbiology·J SpaargarenG P Voorn

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