PMID: 7030526Jul 1, 1981Paper

Sodium, potassium and age: possible determinants of plasma renin activity and aldosterone during childhood (age 4-16)

Clinical Endocrinology
D GoldfarbH Eliahou

Abstract

The renin-angiotensin-aldosterone system was studied in fifty healthy children aged 4-16 years under normal sodium and potassium intake. The plasma renin activity (PRA) and plasma aldosterone (PA) decreased with age: r = -0.30, P less than 0.05 for plasma renin activity and r = -0.33, P less than 0.05 for plasma aldosterone. Significant negative correlation was obtained between plasma renin activity and the 24-h urinary sodium excretion; r = -0.40, P less than 0.01. This relationship remained significant when the daily urinary sodium excretion was corrected for 1.73 m2 body surface area (BSA); r = -0.40, P less than 0.01. Using the multivariance analysis, plotting the plasma renin activity against the two combined parameters (24-h urinary sodium excretion and age), no improvement was obtained (r = 0.38, P greater than 0.05). This finding suggests that during childhood, sodium rather than age has a major modulatory role on plasma renin activity. With advancing age the plasma aldosterone showed a significant positive correlation coefficient with plasma renin activity(r = 0.29, P less than 0.05). Multivariance analysis between plasma aldosterone and the two combined parameters, Plasma renin activity and age, significantly improved...Continue Reading

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Citations

Apr 1, 1993·The Journal of Pediatrics·G A HarshfieldD A Pulliam
Jan 1, 1984·Journal of Chronic Diseases·M UchiyamaK Sakai
Sep 4, 2015·American Journal of Physiology. Renal Physiology·Birgitte Thorsted MahlerSøren Rittig

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