PMID: 7336200Dec 1, 1981Paper

Sodium retention in rats with cadmium-induced hypertension

The Science of the Total Environment
H M Perry, M W Erlanger

Abstract

Chronic feeding of non-toxic doses of cadmium induces an average increase of 15 to 20 mm Hg in indirectly measured systolic pressure of lightly anaesthetized rats. The mechanism of this increase is not known, but cadmium has several potentially pressor effects, including increased sodium retention. This report describes both sodium balance and blood pressure in a pair of experiments where cadmium was fed and in a pair where it was injected. All four cadmium challenges induced sodium retention and also induced hypertension. Thus, rats with either low or moderate chronic exposure to fed cadmium (well below the exposures required to induce toxicity) retained more intraperitoneally injected radiosodium than controls and at the same time developed higher systolic pressures than controls. Immediately following intraperitoneally injected cadmium, rats lost a radiosodium more rapidly than controls; in both situations the blood pressure was higher than the controls. These data indicate that some of the pressor effect associated with cadmium exposure could result from its concomitant antinatriuretic effect.

References

Apr 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·H M PerryJ E Purifoy
Apr 1, 1974·Journal of Pharmaceutical Sciences·J D FoulkeR J Vetter
Aug 1, 1971·Experientia·J Lener, J Musil
Dec 1, 1966·Archives of Environmental Health·H A SchroederJ W Little
Apr 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·M FRIEDMAN, S C FREED

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Citations

Jun 1, 1984·Biological Trace Element Research·D J HorvathJ L Frost
Feb 1, 1983·The Science of the Total Environment·H M Perry, S J Kopp
Jan 25, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M V VaroniV Anania
Jan 1, 1989·Journal of Toxicology and Environmental Health·H M PerryE F Perry
Jun 1, 1988·Environmental Health Perspectives·H M PerryE F Perry
Feb 25, 2006·The Tohoku Journal of Experimental Medicine·Soisungwan SatarugMichael R Moore
Jun 21, 2014·Journal of Ayurveda and Integrative Medicine·Kalyani H Barve, Rahul Chodankar
Mar 1, 1983·Archives of Environmental Health·H M PerryE F Perry
Aug 6, 2009·The American Journal of Chinese Medicine·Liang-Liang PengKai-Fu Ke
Nov 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jamile F GonçalvesMaria Rosa C Schetinger

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