Sodium salicylate: effect on determinants of bile flow and cholesterol solubility in rhesus monkeys

Digestive Diseases and Sciences
M J CooperA R Moossa

Abstract

To study the mechanism of salicylate-induced choleresis in rhesus monkeys, we utilized animals with indwelling common bile duct catheters under phencyclidine anesthesia. Bile flow, [14C]erythritol clearance (an estimate of canalicular flow), and bile acid secretion were measured during baseline and for 1 1/2 hr during salicylate infusion. Bile flow increased from 91.2 +/- 7.3 ml/24 hr (SEM) to 180.1 +/- 8.0 ml/24 hr (P less than 0.001) with salicylate infusion and [14D]erythritol clearance from 114.5 +/- 8.9 ml/24 hr to 222.3 +/- 10.7 ml/24 hr (P less than 0.001), but bile acid secretion was unchanged, suggesting increased bile acid-independent canalicular bile flow. Salicylate concentration in bile averaged 1.48 +/- 0.08 mmol/liter, and salicylate concentration in extra bile produced by salicylate was unlikely to result in chloeresis of the magnitude observed. [3H]inulin bile-plasma ratios, measured in these same studies, were unchanged after salicylate administration, suggesting that permeability of the biliary tree was not altered. Bile lipid secretion, like bile acid secretion, was unchanged after salicylate administration, so no change occurred in the lithogenic index of the bile. These results demonstrate that salicylate ...Continue Reading

References

Nov 1, 1975·The American Journal of Physiology·J ChenderovitchR Infante
Mar 1, 1975·The Journal of Physiology·S C Rutishauser, S L Stone
Jan 1, 1975·The American Journal of Physiology·S M StrasbergJ E Palaheimo
Nov 3, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·A RodaL Barbara
Jun 1, 1973·British Journal of Pharmacology·H S ButtarB H Thomas
May 1, 1968·The Journal of Clinical Investigation·N B Javitt, S Emerman
Jun 1, 1954·The Biochemical Journal·P TRINDER

Citations

Jan 1, 1982·American Journal of Primatology·Charles E Cornelius

Related Concepts

Metazoa
Anthropoidea
Biliary Sludge
Biliary Tract Structure
Epicholesterol
Macaca mulatta
Phospholipids
Secrepan
Sodium Salicylate

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