Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Brain : a Journal of Neurology
Sandy R ShultzTerence J O'Brien

Abstract

Traumatic brain injury is a common and serious neurodegenerative condition that lacks a pharmaceutical intervention to improve long-term outcome. Hyperphosphorylated tau is implicated in some of the consequences of traumatic brain injury and is a potential pharmacological target. Protein phosphatase 2A is a heterotrimeric protein that regulates key signalling pathways, and protein phosphatase 2A heterotrimers consisting of the PR55 B-subunit represent the major tau phosphatase in the brain. Here we investigated whether traumatic brain injury in rats and humans would induce changes in protein phosphatase 2A and phosphorylated tau, and whether treatment with sodium selenate-a potent PR55 activator-would reduce phosphorylated tau and improve traumatic brain injury outcomes in rats. Ninety young adult male Long-Evans rats were administered either a fluid percussion injury or sham-injury. A proportion of rats were killed at 2, 24, and 72 h post-injury to assess acute changes in protein phosphatase 2A and tau. Other rats were given either sodium selenate or saline-vehicle treatment that was continuously administered via subcutaneous osmotic pump for 12 weeks. Serial magnetic resonance imaging was acquired prior to, and at 1, 4, and 1...Continue Reading

References

Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigH Friedburg
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·A C AlonsoK Iqbal
Sep 1, 1993·Journal of Neurochemistry·C X GongK Iqbal
Jul 22, 1998·Journal of Neuroscience Research·H Q Xie, G V Johnson
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Nov 3, 2005·The European Journal of Neuroscience·Fei LiuCheng-Xin Gong
Jan 24, 2007·The European Journal of Neuroscience·Jian-Zhi WangKhalid Iqbal
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Estelle SontagTeodoro Bottiglieri
Mar 21, 2007·Acta Neuropathologica·Bin LiKhalid Iqbal
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emmanuel PlanelKaren E Duff
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Aug 9, 2007·Nature Reviews. Neuroscience·Carlo BallatoreJohn Q Trojanowski
Dec 7, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cindy L LiuBingren R Hu
Feb 23, 2008·Trends in Biochemical Sciences·Veerle JanssensJozef Goris
Jul 1, 2008·Neurobiology of Disease·Xin-Wen ZhouJin-Jing Pei
Dec 9, 2008·Journal of Neurotrauma·Nigel C JonesTerence J O'Brien
Feb 3, 2009·Acta Neuropathologica·Khalid IqbalInge Grundke-Iqbal
Apr 14, 2009·Journal of Alzheimer's Disease : JAD·Zhihou LiangCheng-Xin Gong
Jul 17, 2009·Journal of Neurotrauma·Viviane BouilleretTerence J O'Brien
Oct 13, 2009·NeuroImage·Brian B AvantsJames C Gee
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kathryn E SaatmanRamesh Raghupathi
Jun 12, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Niall M CorcoranChristopher M Hovens
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Janet van EerselLars M Ittner
Nov 6, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ying R LiuViviane Bouilleret
May 11, 2011·Neuron·Meaghan MorrisLennart Mucke

❮ Previous
Next ❯

Citations

Mar 15, 2016·Frontiers in Integrative Neuroscience·Venkata S S S SajjaPamela J VandeVord
Apr 28, 2016·Journal of Neuroinflammation·Stuart J McDonaldSandy R Shultz
Jul 23, 2016·Journal of Alzheimer's Disease : JAD·Charles B MalpasTerence J O'Brien
Apr 6, 2018·International Journal of Molecular Sciences·Marina P SánchezJosé M Serratosa
Apr 13, 2018·Journal of Neurotrauma·Mitchell T CaprelliCharles H Tator
Dec 12, 2017·Brain Injury : [BI]·Maddison R JohnstoneStuart J McDonald
Jan 13, 2018·Reviews in the Neurosciences·Nitika GargBikash Medhi
Jun 15, 2018·Journal of Neurotrauma·Xin Lin TanSandy R Shultz
May 15, 2018·Journal of Neurotrauma·Douglas S DeWittLiying Zhang
Jan 12, 2019·British Journal of Pharmacology·Sara NiksereshtScott Ayton
Jun 7, 2019·Journal of Neuropathology and Experimental Neurology·Grant L IversonRudolph J Castellani
Jul 25, 2019·Frontiers in Cellular Neuroscience·Wei ChenPing Zheng
Nov 2, 2019·Brain : a Journal of Neurology·Grant L IversonRudolph J Castellani
Feb 13, 2020·Journal of Neurotrauma·Jessica M CollinsJenna M Ziebell
Apr 25, 2018·Frontiers in Immunology·Olga N Kokiko-Cochran, Jonathan P Godbout
Mar 15, 2019·Epilepsia Open·Francesco M Noé, Nicola Marchi
Aug 19, 2020·Molecular Neurobiology·Elnaz NakhjiriKoorosh Shahpasand
Sep 15, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Barbara R CardosoAshley I Bush
Oct 7, 2017·Nature Reviews. Drug Discovery·Chuanzhou Li, Jürgen Götz
Sep 15, 2017·Annals of Clinical and Translational Neurology·David K WrightRichelle Mychasiuk
Dec 20, 2018·Annals of Clinical and Translational Neurology·Ryan C WortmanSandy R Shultz
Jun 12, 2020·Epilepsia Open·Pablo M Casillas-EspinosaTerence J O'Brien
Jun 14, 2018·Nature Reviews. Neurology·Erin E Congdon, Einar M Sigurdsson
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mitchell T CaprelliCharles H Tator

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.