PMID: 7517162Mar 1, 1994Paper

Sodium selenite therapy and thyroid-hormone status in cystic fibrosis and congenital hypothyroidism

Biological Trace Element Research
E KaufK Winnefeld

Abstract

The effectiveness of a peroral sodium selenite therapy (115 micrograms Se/m2 BSA/d) administered to cystic fibrosis patients (n = 32) could after three months be identified in a significant serum selenium increase (0.69-->0.96 mumol/L), a significant malondialdehyde decrease (2.72-->1.64 mumol/L), as well as in a significant serum vitamin E increase (4.31-->5.72 micrograms/mL). Parallel to that, a serum T3 increase as well as a highly significant decrease in the serum T4/T3-ratio were found, too, which point to improved peripheral T4-->T3 conversion during selenium medication. Type-I-iodothyronine-5'-deiodinase has recently been identified as a specific selenoenzyme. In the case of congenital hypothyroidism (n = 37) application of sodium selenite in the above specified dosage yielded a mean serum selenium increase (0.87-->1.12 mumol/L), a not significant T3 increase (2.57-->2.61 nmol/L) as well as a not significant TSH decrease (5.34-->4.49 mIU/L) without an expected T4 decrease. With the serum lipids, however, a lowering of total cholesterol (4.85-->4.53 mmol/L) simultaneous with a mean increase in HDL-cholesterol (1.52-->1.66 mmol/L) as well as a decrease in LDL-cholesterol (2.93-->2.52) could be observed. We view the reducti...Continue Reading

Citations

Jun 24, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Jun 1, 2003·Nutrition Research Reviews·Graham LyonsRobin Graham
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Josef Köhrle
Aug 1, 2013·International Archives of Occupational and Environmental Health·Olga ParshukovaEvgeny Bojko
Oct 11, 2012·Clinical Endocrinology·Anne DrutelPhilippe Caron
May 19, 2005·Hormone Research·Cecilia VoltaSergio Bernasconi
Jan 1, 2010·Nutrition and Metabolic Insights·Johanne PoirierStan Kubow
Mar 1, 2018·European Journal of Pediatrics·Aris GiannakopoulosStavros Doudounakis
Sep 22, 2005·Endocrine Reviews·J KöhrleJ E Dumont
Nov 11, 2003·The Journal of Nutrition·Wayne Chris Hawkes, Nancy L Keim

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