PMID: 9417150Jan 17, 1998Paper

Sodium space and intravascular volume: dietary sodium effects in cystic fibrosis and healthy adolescent subjects

Pediatrics
G J LegrisC F Doershuk

Abstract

To assess the physiologic response to salt depletion in subjects with cystic fibrosis (CF) and control male adolescents for sodium balance, sodium space, and stimulation of the renin-angiotensin-aldosterone axis. Seven subjects with CF and six controls received a salt-replete (150 or 290 mmol NaCl per day) diet and then a salt-deplete (10 mmol NaCl per day) diet while in a clinical research center. Space maintenance: CF subjects responded to salt depletion with a greater weight loss than did controls (1.9 vs 0.8 kg) and a decrease in 24Na+ space, whereas controls maintained 24Na+ space. Paired (Na-deplete/Na-replete) blood volumes decreased in subjects with CF, but not in controls. Renin-angiotensin-aldosterone axis stimulation: During salt repletion, subjects with CF had significantly higher aldosterone values than did controls in the afternoon, but not at 7:00 AM. During salt depletion, plasma renin activity and aldosterone increased significantly more in subjects with CF than in controls (renin, 35 vs 13 ng/mL/hour [9.7 vs 3.6 ng.L-1 s-1]; aldosterone: 181 vs 101 ng/dL [5021 vs 2802 pmol/L]). Furthermore, the angiotensin antagonist saralasin increased renin much more in subjects with CF (154 vs 36 ng/mL per hour [43 vs 10 ng...Continue Reading

Citations

Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Aug 2, 2008·Public Health Nutrition·Paraskevi K TsartsaliRussell Jago
Dec 9, 2004·Pediatric Research·An-Chian ChenSharon M Donovan
Dec 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabetta Scurati-ManzoniSebastiano A G Lava
May 10, 2011·Revue des maladies respiratoires·J ChapronP-R Burgel
Nov 26, 2009·Pediatric Clinics of North America·Suzanne H MichelMaria Mascarenhas
May 17, 2006·Pediatric Pulmonology·Gaudenz M HafenPhilip J Robinson
Oct 6, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Alison J CoatesTom Marshall
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Drucy BorowitzVirginia Stallings
Jun 7, 2020·Indian Journal of Pediatrics·Mohsin Raj MantooS K Kabra
May 29, 2018·Journal of the Academy of Nutrition and Dietetics·Mary Rozga, Deepa Handu

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