Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model

Molecular Medicine Reports
Fang ChenZhongzhi Tang

Abstract

The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS. In the HS groups, the rats were removed from the ATC and allowed to recover at 26˚C for 0, 2, 6 or 12 h. In the STS‑HS groups, the rats received femoral vein injections of 5‑40 mg/kg STS immediately following the onset of HS and were subsequently placed at a temperature of 26˚C to recover for 6 h. In the present study, the serum levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β and IL‑6 were assessed using ELISA, and the numbers of apoptotic aortic endothelial cells were investigated using terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick‑end labeling combined with immunofluorescence. In the HS groups, the serum levels of TNF‑α, IL‑1β and IL‑6, as well as the numbers of ap...Continue Reading

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Citations

May 6, 2020·Journal of Thrombosis and Haemostasis : JTH·Elizabeth A ProctorLisa R Leon
Mar 28, 2018·Experimental and Therapeutic Medicine·Hong Liu, Mingming Cai
Jan 29, 2020·Journal of Cellular and Molecular Medicine·Da-Peng ZhangShi-Jie Zhang
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhong-Yan ZhouJing-Yi Tang
Jan 20, 2021·Expert Review of Clinical Pharmacology·Jun FengJunshuai Wang

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

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