Sodium taurocholate modifies the bile acid-independent fraction of canalicular bile flow in the rhesus monkey

The Journal of Clinical Investigation
A L BakerJ L Boyer

Abstract

Bile acid-independent secretion and the choleretic response to taurocholate were determined in rhesus monkeys fitted with indwelling silastic cannulas in the common bile ducts. Bile acids were infused intravenously in random order at 3.5, 7.0, or 10.5 mumol/min for 1.5 h each. When data were analyzed with a single regression line, bile flow increased in proportion to the level of bile acid secretion, although the y-intercepts (the conventional measurement of bile acid-independent secretion) varied widely (77.9+/-40.9 ml/24 h). The variation in y-intercepts was observed between animals and with repeated studies in the same animal and could not be explained by sex differences or the effects of the indwelling silastic cannulas, but seemed to be related to the order of bile acid infusion. With only two taurocholic acid infusion rates (7.0 and 3.5 mumol/min), [(14)C]erythritol clearance was greater per mole of secreted bile acid when the initial bile acid infusion was at the high level, but approached zero at low bile acid secretion rates, which suggests that so-called bile acid-independent canalicular flow is closely related to bile acid secretion or is small in size. The augmentation in [(14)C]erythritol clearance when the high in...Continue Reading

References

Feb 1, 1978·The Journal of Clinical Investigation·R J WannagatR K Ockner
Jan 1, 1977·Annual Review of Physiology·E L Forker
Nov 1, 1978·The Journal of Clinical Investigation·B L Blitzer, J L Boyer
Dec 1, 1978·The Journal of Clinical Investigation·T J LaydenJ L Boyer
Feb 1, 1975·European Journal of Clinical Investigation·D Prandi
Oct 1, 1974·The Journal of Clinical Investigation·J L Boyer, J R Bloomer
May 1, 1968·The Journal of Clinical Investigation·N B Javitt, S Emerman
Apr 1, 1969·The Journal of Clinical Investigation·E L Forker

Citations

Mar 1, 1984·Digestive Diseases and Sciences·D L Kaminski, Y G Deshpande
Jan 1, 1982·Digestive Diseases and Sciences·M H LewisA R Moossa
Jun 1, 1988·Digestive Diseases and Sciences·L LimlomwongseN Krishnamra
Jan 1, 1982·American Journal of Surgery·C A GarberoglioA R Moossa
Apr 1, 1980·The Journal of Clinical Investigation·F R SimonR A Davis
Sep 1, 1985·The Journal of Surgical Research·B D SchirmerR S Jones
Apr 1, 1983·The Journal of Surgical Research·B D SchirmerR S Jones
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D P ClelandB H Billing
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Reuben
May 11, 1991·Journal of Hepatology·M L ShiffmanE W Moore
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B G EriczonB Angelin
Jul 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J B Watkins, C D Klaassen
Jul 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Erlinger
Jun 1, 1983·European Journal of Clinical Investigation·O Mathisen, M Raeder
Jun 1, 1991·Scandinavian Journal of Gastroenterology·E Omland, O Mathisen
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·S M Strasberg
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M S Anwer, D Hegner

Related Concepts

Anthropoidea
Biliary Sludge
Bile Salts
Erythritol
Parenteral Infusion
Macaca mulatta
Taurocholic Acid, Monolithium Salt

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