Sodium thiosulfate: new hope for the treatment of calciphylaxis

Seminars in Dialysis
Melvin R Hayden, David Goldsmith

Abstract

Calciphylaxis/calcific uremic arteriolopathy is rare but an important cause of morbidity and mortality in patients with chronic and end-stage kidney disease with increasing prevalence. Intravenous sodium thiosulfate (STS) has rapidly emerged from a seldom used therapy for the treatment of calciphylaxis/calcific uremic arteriolopathy to a treatment that is being increasingly utilized globally due to multiple positive outcomes shared in the form of case reports and reviews during the past 6 years. Its role as a rather potent antioxidant has uniquely been associated with a prompt decrease in pain and its slower chelating properties are associated with regression of subcutaneous calcifications. Excessive reactive oxygen species (ROS) activate nuclear transcription factor, NF(kappa)B and downstream cytokines resulting in inflammation, which may result in dysregulated hepatic protein synthesis. Indeed, inflammation activates acute-phase reactant synthesis, while concurrently inhibiting synthesis of fetuin-A (an inhibitor of extraosseous calcification) and the antioxidant albumin. Additionally, ROS may decrease locally synthesized matrix GLA proteins and this combination may contribute to increased vascular and subcutaneous calcificat...Continue Reading

References

Jun 14, 1969·British Medical Journal·J K Rees, G A Coles
Jul 9, 2002·Seminars in Dialysis·William A Wilmer, Cynthia M Magro
Aug 5, 2003·The Journal of Clinical Investigation·Cora SchaferWilli Jahnen-Dechent
Jan 1, 1962·Perspectives in Biology and Medicine·H SELYE
Jan 1, 1962·Dermatologica·N PADMANABHANH SELYE
May 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey S CiconeDavid A Spector
May 19, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·M MeissnerJ Gille
Mar 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ralf WestenfeldWilli Jahnen-Dechent
Mar 29, 2008·International Urology and Nephrology·Melvin R HaydenRamesh Khanna
Apr 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sagar U NigwekarJohn K Hix
May 14, 2008·FEBS Letters·Marjolaine RocheEmmanuel Bourdon
Jun 27, 2008·Clinical Nuclear Medicine·Sushane Soni, William D Leslie
Jul 17, 2008·Clinical and Experimental Dermatology·B C HackettB F O'Donnell
Jul 26, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Colette B Raymond, Lori D Wazny
Oct 1, 2008·The International Journal of Artificial Organs·I KyritsisB Agroyannis
Oct 23, 2008·Current Opinion in Nephrology and Hypertension·Natasha M Rogers, Patrick Toby H Coates
May 29, 2009·American Journal of Physiology. Renal Physiology·Utpal SenSuresh C Tyagi
Aug 25, 2009·Nature Reviews. Nephrology·Georg SchlieperJürgen Floege
Sep 30, 2009·Nature Reviews. Nephrology·Kai-Uwe Eckardt, Bertram L Kasiske
Mar 25, 2010·Seminars in Dialysis·Mark J Courtney, Neesh Pannu
Mar 25, 2010·Seminars in Dialysis·Natasha M Rogers, P Toby H Coates
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kurt M Sowers, Melvin R Hayden

❮ Previous
Next ❯

Citations

Jan 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emanuel ZittKarl Lhotta
Jan 19, 2013·The American Journal of Dermatopathology·Mark C MochelMai P Hoang
Feb 1, 2013·American Journal of Nephrology·Meteb M AlBugamiSteven D Soroka
Jun 27, 2013·Disease Models & Mechanisms·Qiaoli LiJouni Uitto
Dec 19, 2013·Anais Brasileiros De Dermatologia·Silvio Alencar MarquesMariângela Esther Alencar Marques
Aug 13, 2011·American Journal of Clinical Dermatology·Matteo AuriemmaPaolo Amerio
Jun 14, 2013·Journal of Pharmacology & Pharmacotherapeutics·Lucas GascoVikhyat S Bebarta
Jul 11, 2013·Case Reports in Urology·Vincenzo BarberaAlberto Santoboni
Feb 10, 2016·Journal of Neuroinflammation·Moonhee LeePatrick L McGeer
Mar 23, 2011·International Journal of Nephrology·Saurabh K GoelPeter A McCullough
Jul 13, 2011·International Journal of Nephrology·Nicholas NewDwarakanathan Ranganathan
Jul 31, 2012·Actas dermo-sifiliográficas·V M Leis-DosilR M Díaz-Díaz
Aug 9, 2011·Journal of the American Academy of Dermatology·Chetan VedvyasRuth Ann Vleugels
Jan 21, 2014·Seminars in Dialysis·Femke M MolenaarBrigit C van Jaarsveld
Apr 1, 2014·The Journal of the American College of Clinical Wound Specialists·Natallia MarozRichard Simman
May 12, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sagar U NigwekarRavi I Thadhani
Dec 3, 2014·Nitric Oxide : Biology and Chemistry·Pauline M SnijderHarry van Goor
Apr 29, 2015·Annales d'endocrinologie·Vincent GuigonisAgnès Linglart
Apr 21, 2012·International Journal of Nephrology·Usman Hammawa MalabuKunwarjit Singh Sangla
Jul 23, 2013·The American Journal of Pathology·Sundararaman SwaminathanKim M Hiatt
Feb 7, 2015·Nitric Oxide : Biology and Chemistry·Anne M KoningHarry van Goor
Apr 8, 2016·The Journal of Dermatological Treatment·Pieter Bourgeois, Petra De Haes
Dec 14, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Arthur MageauHang-Korng Ea
Mar 23, 2017·International Wound Journal·Kirsi IsoherranenNicolas Kluger
Jun 21, 2017·International Journal of Molecular Sciences·Anna Bilska-WilkoszDanuta Kowalczyk-Pachel
Nov 6, 2018·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Jacqueline M ZilliouxMikel Gray
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Else van den BergStephan J L Bakker
Sep 16, 2015·Current Opinion in Nephrology and Hypertension·Sagar U Nigwekar
Oct 16, 2015·Electrophoresis·Paweł KubalczykRafał Głowacki
Mar 18, 2020·Indian Journal of Dermatology·Lili RóbertBernadett Hidvégi
Apr 23, 2019·Advances in Skin & Wound Care·John J Chang
Oct 16, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I LobbA Sener
May 1, 2021·International Journal of Molecular Sciences·Briana K ShimadaOlivier Le Saux

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
Sagar U NigwekarEduardo Lacson
Archives of Dermatology
D LipskerC Francès
Clinical Journal of the American Society of Nephrology : CJASN
Sagar U NigwekarJohn K Hix
© 2021 Meta ULC. All rights reserved